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Nucleolar URB1 ensures 3′ ETS rRNA removal to prevent exosome surveillance
The nucleolus is the most prominent membraneless condensate in the nucleus. It comprises hundreds of proteins with distinct roles in the rapid...
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Full-length 16S rRNA gene sequencing by PacBio improves taxonomic resolution in human microbiome samples
BackgroundSequencing variable regions of the 16S rRNA gene (≃300 bp) with Illumina technology is commonly used to study the composition of human...
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Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15
Mitochondrial rRNA modifications are essential for mitoribosome assembly and its proper function. The m 4 C methyltransferase METTL15 maintains...
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A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei
Trypanosomes are protozoan parasites that cycle between insect and mammalian hosts and are the causative agent of slee** sickness. Here, we...
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High-throughput identification and quantification of bacterial cells in the microbiota based on 16S rRNA sequencing with single-base accuracy using BarBIQ
Bacteria often function as a community, called the microbiota, consisting of many different bacterial species. The accurate identification of...
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Full-Length 16S rRNA Gene Analysis Using Long-Read Nanopore Sequencing for Rapid Identification of Bacteria from Clinical Specimens
Amplicon sequencing of the 16S ribosomal RNA (rRNA) gene is a practical and reliable measure for taxonomic profiling of bacterial communities. This...
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Gut Microbiota in Children with Hand Foot and Mouth Disease on 16S rRNA Gene Sequencing
Hand foot and mouth disease (HFMD) is a contagious and seasonal viral disease in children. The gut microbiota of HFMD children is not clear now. The...
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VapC toxin switches M. smegmatis cells into dormancy through 23S rRNA cleavage
Mycobacterium tuberculosis is an extremely successful pathogen known for its ability to cause latent infection. The latter is connected with the...
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Study on the Bioconversion of Curcumin to Calebin-A Using Spirulina subsalsa and Its Taxonomic Resolution Using 16S rRNA Analysis
Due to morphological convergence and the application of numerous taxonomic concepts, the systematics of filamentous cyanobacteria is still a...
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Evaluation of Full-Length Versus V4-Region 16S rRNA Sequencing for Phylogenetic Analysis of Mouse Intestinal Microbiota After a Dietary Intervention
The composition of microbial communities is commonly determined by sequence analyses of one of the variable (V) regions in the bacterial 16S rRNA...
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Emu: species-level microbial community profiling of full-length 16S rRNA Oxford Nanopore sequencing data
16S ribosomal RNA-based analysis is the established standard for elucidating the composition of microbial communities. While short-read 16S rRNA...
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Phylogenies of the 16S rRNA gene and its hypervariable regions lack concordance with core genome phylogenies
BackgroundThe 16S rRNA gene is used extensively in bacterial phylogenetics, in species delineation, and now widely in microbiome studies. However,...
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Characterization of the mitochondrial Huso huso genome and new aspects of its organization in the presence of tandem repeats in 12S rRNA
BackgroundThe sturgeon group has been economically significant worldwide due to caviar production. Sturgeons consist of 27 species in the world....
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16S rRNA Methyltransferases as Novel Drug Targets Against Tuberculosis
Tuberculosis (TB) is an airborne infectious disease caused by Mycobacterium tuberculosis ( M.tb ) whose natural history traces back to 70,000 years. TB...
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Analysis of the bacterial and fungal populations in South African sorghum beer (umqombothi) using full-length 16S rRNA amplicon sequencing
There is a need to profile microorganisms which exist pre-and-post-production of umqombothi , to understand its microbial diversity and the...
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Targeting the human gut microbiome with small-molecule inhibitors
The human gut microbiome is a complex microbial community that is strongly linked to both host health and disease. However, the detailed molecular...
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Methionine regulates self-renewal, pluripotency, and cell death of GIC through cholesterol—rRNA axis
BackgroundGlioma-initiating cells (GICs) are the source of glioma cells that can self-renew, have pluripotency, and are treatment-resistant, so are...
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18S rRNA variability maps reveal three highly divergent, conserved motifs within Rotifera
Background18S rRNA is a major component of the small subunit of the eukaryotic ribosome and an important phylogenetic marker for many groups, often...
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Single-molecule targeted accessibility and methylation sequencing of centromeres, telomeres and rDNAs in Arabidopsis
The short read-length of next-generation sequencing makes it challenging to characterize highly repetitive regions (HRRs) such as centromeres,...
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Small molecule inhibitors targeting m6A regulators
As the most common form of epigenetic regulation by RNA, N 6 methyladenosine (m 6 A) modification is closely involved in physiological processes, such...
