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Estimating pulmonary arterial remodeling via an animal-specific computational model of pulmonary artery stenosis
Pulmonary artery stenosis (PAS) often presents in children with congenital heart disease, altering blood flow and pressure during critical periods of...
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A computational growth and remodeling framework for adaptive and maladaptive pulmonary arterial hemodynamics
Hemodynamic loading is known to contribute to the development and progression of pulmonary arterial hypertension (PAH). This loading drives changes...
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Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model
BackgroundPulmonary arterial hypertension (PAH) is a progressive and devastating disease characterized by pulmonary vascular remodeling which is...
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Protective effects of calcyclin-binding protein against pulmonary vascular remodeling in flow-associated pulmonary arterial hypertension
BackgroundPulmonary arterial hypertension associated with congenital heart disease (CHD-PAH) is recognized as a cancer-like disease with a...
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Pathogenesis of Pulmonary Arterial Hypertension
The pathogenic mechanisms by which pulmonary arterial hypertension (PAH) develops and progresses are complex and not fully elucidated. Considerable...
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Triple-tyrosine kinase inhibition by BIBF1000 attenuates airway and pulmonary arterial remodeling following chronic allergen challenges in mice
BackgroundAirway remodeling is an important pathological feature of chronic airway diseases, which leads to a progressive decline in lung function....
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The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension
BackgroundAbnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial smooth muscle...
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Prostaglandin and prostaglandin receptors: present and future promising therapeutic targets for pulmonary arterial hypertension
BackgroundPulmonary arterial hypertension (PAH), Group 1 pulmonary hypertension (PH), is a type of pulmonary vascular disease characterized by...
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Ethyl pyruvate alleviates pulmonary arterial hypertension via PI3K-Akt signaling
Pulmonary arterial hypertension (PAH) is a pathophysiological syndrome that is extremely difficult to manage, and there is currently no effective...
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Characterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension
BackgroundDespite causing increased morbidity and mortality, pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) patients...
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Overview of Pulmonary Arterial Hypertension in Pregnancy
Pulmonary arterial hypertension (PAH) is a pathological condition characterized by constriction of the distal pulmonary vasculature and resultant...
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Characterization of pulmonary arterial stiffness using cardiac MRI
Pulmonary arterial stiffness (PAS) is a pathologic hallmark of all types of pulmonary hypertension (PH). Cardiac MRI (CMR), a gold-standard imaging...
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JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a chronic disorder characterized by hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs)....
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Neutrophil extracellular traps promote proliferation of pulmonary smooth muscle cells mediated by CCDC25 in pulmonary arterial hypertension
BackgroundPrevious studies have indicated that neutrophil extracellular traps (NETs) play a pivotal role in pathogenesis of pulmonary arterial...
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CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension
BackgroundPulmonary arterial hypertension (PAH) is a rare but fatal cardiopulmonary disease mainly characterized by pulmonary vascular remodeling....
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Targeting Epigenetics in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a fatal and enigmatic disease of the pulmonary circulatory system for which there is currently no cure. The...
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Charting the cellular landscape of pulmonary arterial hypertension through single-cell omics
This review examines how single-cell omics technologies, particularly single-cell RNA sequencing (scRNAseq), enhance our understanding of pulmonary...
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Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension
Right ventricular (RV) function is critical to prognosis in all forms of pulmonary hypertension. Here we perform molecular phenoty** of RV...
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Medical Management of Right Ventricular Dysfunction in Pulmonary Arterial Hypertension
Purpose of ReviewThe purpose of this review is to overview the most relevant and recent knowledge regarding medical management in pulmonary arterial...
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Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development
Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the remodeling of pulmonary blood vessels. If left unaddressed, PAH...
