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Transcriptomic and metabolomic analysis provides insight into imazethapyr toxicity to non-target plants
Imazethapyr is a widely used imidazolinone herbicide worldwide, and its potential adverse effects on non-target plants have raised concerns....
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DPYD genetic polymorphisms in non-European patients with severe fluoropyrimidine-related toxicity: a systematic review
BackgroundPre-treatment DPYD screening is mandated in the UK and EU to reduce the risk of severe and potentially fatal fluoropyrimidine-related...
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Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates
Background6-Bromo-7-[ 11 C]methylpurine ([ 11 C]BMP) is a radiotracer for positron emission tomography (PET) to measure multidrug resistance-associated...
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Efficacy and non-toxicity of ciclopirox olamine-loaded liposomes against Cryptococcus neoformans clinical isolates
The aim of this study was to evaluate the efficacy and non-toxicity of ciclopirox olamine-loaded liposomes against Cryptococcus neoformans clinical...
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Dinitroaniline herbicides: a comprehensive review of toxicity and side effects on animal non-target organisms
The widespread use of herbicides has increased concern about the hazards and risks to animals living in terrestrial and aquatic ecosystems. A...
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Chemical composition and toxicity of commercial Mentha spicata and Eucalyptus citriodora essential oils on Culex quinquefasciatus and non-target insects
Current vector control strategies based on synthetic chemicals are not eco-friendly against non-target organisms; hence, alternative approaches are...
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Toxicity analysis and behavior of nano-particles in leachate from non-engineered landfill sites of Chandigarh, Mohali, and Panchkula cities-Tricity
The study presents an analysis of assessment of human risk due to leachate from three non-engineered landfill sites of Chandigarh, Mohali, and...
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Improved overall survival in patients develo** endocrine toxicity during treatment with nivolumab for advanced non-small cell lung cancer in a prospective study
PurposeImmune checkpoint inhibitors (ICPIs) disrupting PD-1/PD-L1 axis have revolutionized the management of advanced non-small cell lung cancer...
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Short-term toxicity of chloroacetanilide herbicide on non-target organism: estimation of median-lethal concentration, hematological, biochemical, ion regulation, and antioxidants
Contamination of agricultural chemicals (including pesticides) raises concerns about the safety of the aquatic ecosystem. Pretilachlor is a...
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Evaluation of the toxicity of a new series of α-aminophosphonate derivatives in a target (Ephestia Kuehniella) and non-target (Lumbricus rubellus) population
ObjectA new series of ᾳ-aminophosphonate derivatives was evaluated for their toxicity in a target ( Ephestia kuehniella ) and non-target ( Lumbricus...
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Efficacy and toxicity of stereotactic body radiotherapy for un-resectable stage III non-small cell lung cancer patients unfit for concurrent chemoradiation therapy: a retrospective study
BackgroundIn this study, we evaluated the efficacy and toxicity of stereotactic body radiotherapy (SBRT) as replacement strategy of conventionally...
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Lessening the Impact of Financial Toxicity (LIFT): a protocol for a multi-site, single-arm trial examining the effect of financial navigation on financial toxicity in adult patients with cancer in rural and non-rural settings
BackgroundAlmost half of the patients with cancer report cancer-related financial hardship, termed “financial toxicity” (FT), which affects...
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Ovicidal toxicity of plant essential oils and their major constituents against two mosquito vectors and their non-target aquatic predators
Plant essential oil (EO) is a natural alternative to synthetic chemical insecticides for mosquito control. EOs from Citrus aurantium L., Cymbopogon...
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Non-optimal ambient temperatures aggravate insecticide toxicity and affect honey bees Apis mellifera L. gene regulation
In this study, we conducted a transcriptional analysis of five honey bee genes to examine their functional involvement vis-à-vis ambient temperatures...
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Incidence of and risk factors for non-hematologic toxicity with combined radiotherapy and CDK4/6 inhibitors in metastatic breast cancer using dose-volume parameters analysis: a multicenter cohort study
BackgroundThere is a lack of data on combined radiotherapy (RT) and cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6i) risk factors and toxicity....
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Sorptive elimination of ibuprofen using activated biochar: modelling, non-linear isotherm and kinetic, cost assessment and toxicity analysis
The prevalence of numerous pharmaceuticals in sewage effluent discharges has significantly decreased the life and quality of water bodies. Ibuprofen...
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Status of pharmaceuticals in the Korle Lagoon and their toxicity to non-target organisms
The availability of pharmaceutically active compounds (PhACs) in surface waters and suspended solids/sediments presents an ecological hazard of...
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Randomized Versus Real-World Evidence on the Efficacy and Toxicity of Checkpoint Inhibitors in Cancer in Patients with Advanced Non-small Cell Lung Cancer or Melanoma: A Meta-analysis
BackgroundBoth randomized controlled trials (RCTs) and real-world evidence (RWE) studies provide results regarding the efficacy and toxicity of...
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Ferroptosis as a mechanism of non-ferrous metal toxicity
Ferroptosis is a recently discovered form of regulated cell death, implicated in multiple pathologies. Given that the toxicity elicited by some...
