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Distinct roles of Arabidopsis ORC1 proteins in DNA replication and heterochromatic H3K27me1 deposition
Most cellular proteins involved in genome replication are conserved in all eukaryotic lineages including yeast, plants and animals. However, the...
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Interplay of pericentromeric genome organization and chromatin landscape regulates the expression of Drosophila melanogaster heterochromatic genes
BackgroundTranscription of genes residing within constitutive heterochromatin is paradoxical to the tenets of epigenetic code. The regulatory...
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Study of the Association of Ouib and Nom with Heterochromatin in Drosophila melanogaster
AbstractIn Drosophila , a large group of actively transcribed genes is located in pericentromeric heterochromatin. It is assumed that heterochromatic...
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Epigenetic Regulation of Fungal Genes Involved in Plant Colonization
Plant-pathogenic fungi have a major impact on agriculture and human health, as well as a remarkable ability to adapt to new conditions. This...
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Determining the Compaction State of Genes Using DNA FISH
DNA fluorescence in situ hybridization (FISH) enables the visualization of chromatin architecture and the interactions between genomic loci at a...
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Assessment of reference genes for qRT-PCR normalization to elucidate host response to African swine fever infection
Viral infection disrupts the normal regulation of the host gene’s expression. In order to normalise the expression of dysregulated host genes upon...
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Epigenetics of Ribosomal RNA Genes
AbstractThis review is focused on biology of genes encoding ribosomal RNA (rRNA) in mammals. rRNA is a structural component of the most abundant...
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Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements
Heterochromatin, typically marked by histone H3 trimethylation at lysine 9 (H3K9me3) or lysine 27 (H3K27me3), represses different protein-coding...
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Protein-Coding Genes
Proteins are the major effectors of cell functions. Protein-coding genes evolve from ancestral genes by gene duplication, recombination,...
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Transcription regulates the spatio-temporal dynamics of genes through micro-compartmentalization
Although our understanding of the involvement of heterochromatin architectural factors in sha** nuclear organization is improving, there is still...
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The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes
Herpes simplex virus 1 ( HSV-1 ) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection,...
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A pair of gametologous genes provides further insights into avian comparative cytogenomics
Exploration of avian gametologous genes, i.e., homologous genes located on both the Z and W chromosomes, provides a crucial information about the...
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Transcriptional and post-transcriptional regulation of young genes in plants
BackgroundNew genes continuously emerge from non-coding DNA or by diverging from existing genes, but most of them are rapidly lost and only a few...
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H3.1K27me1 loss confers Arabidopsis resistance to Geminivirus by sequestering DNA repair proteins onto host genome
The H3 methyltransferases ATXR5 and ATXR6 deposit H3.1K27me1 to heterochromatin to prevent genomic instability and transposon re-activation. Here, we...
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Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability
ASARs are long noncoding RNA genes that control replication timing of entire human chromosomes in cis. The three known ASAR genes are located on...
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Epigenetic Control of Gene Expression
Genetic mutations lead to inheritable changes in the traits. Alterations in genetic features may also be caused by chromatin modifications without...
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Epigenetic genes and epilepsy — emerging mechanisms and clinical applications
An increasing number of epilepsies are being attributed to variants in genes with epigenetic functions. The products of these genes include factors...
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Cyto-molecular characterization of rDNA and chromatin composition in the NOR-associated satellite in Chestnut (Castanea spp.)
The American chestnut ( Castanea dentata , 2 n = 2 x = 24), once known as the “King of the Appalachian Forest”, was decimated by chestnut blight during...
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Genome wide inherited modifications of the tomato epigenome by trans-activated bacterial CG methyltransferase
BackgroundEpigenetic variation is mediated by epigenetic marks such as DNA methylation occurring in all cytosine contexts in plants. CG methylation...
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Impacts of DNA methylases and demethylases on the methylation and expression of Arabidopsis ethylene signal pathway genes
Arabidopsis ethylene (ET) signal pathway plays important roles in various aspects. Cytosine DNA methylation is significant in controlling gene...
