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SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity
Cancer cells evade T cell-mediated killing through tumour–immune interactions whose mechanisms are not well understood
1 ,2 . Dendritic cells (DCs),...
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Monitoring and modelling the glutamine metabolic pathway: a review and future perspectives
BackgroundAnalysis of the glutamine metabolic pathway has taken a special place in metabolomics research in recent years, given its important role in...
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The tRNA Gm18 methyltransferase TARBP1 promotes hepatocellular carcinoma progression via metabolic reprogramming of glutamine
Cancer cells rely on metabolic reprogramming to sustain the prodigious energetic requirements for rapid growth and proliferation. Glutamine...
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Targeting Glutamine Metabolism as an Attractive Therapeutic Strategy for Acute Myeloid Leukemia
Relapse after chemotherapy and hematopoietic stem cell transplantation leads to adverse prognosis for acute myeloid leukemia (AML) patients. As a...
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A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle
Glutamine metabolism plays a pivotal role in cancer progression, immune cell function, and the modulation of the tumor microenvironment. Dysregulated...
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YAP governs cellular adaptation to perturbation of glutamine metabolism by regulating ATF4-mediated stress response
Proliferating cells have metabolic dependence on glutamine to fuel anabolic pathways and to refill the mitochondrial carbon pool. The Hippo pathway...
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Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis
As one of the most successful human pathogens, Mycobacterium tuberculosis ( Mtb ) has evolved a diverse array of determinants to subvert host immunity...
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Glutamine induces remodeling of tight junctions in Caco-2 colorectal cancer cell
Malignant cells often exhibit significant metabolic alterations, including the utilization of different nutrients to meet energetic and biosynthetic...
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CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions
Exposure of lipopolysaccharide triggers macrophage pro-inflammatory polarization accompanied by metabolic reprogramming, characterized by elevated...
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Microfluidic devices for precise measurements of cell directionality reveal a role for glutamine during cell migration
Cancer cells that migrate from tumors into surrounding tissues are responsible for cancer dissemination through the body. Microfluidic devices have...
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L-glutamine for sickle cell disease: more than reducing redox
Oxidative stress is a major contributor to the pathophysiology of sickle cell disease (SCD) including hemolysis and vaso-occlusive crisis (VOC)....
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Antitumor activity of mianserin (a tetracyclic antidepressant) primarily driven by the inhibition of SLC1A5-mediated glutamine transport
Targeting tumor metabolic vulnerabilities such as “glutamine addiction” has become an attractive approach for the discovery of novel antitumor...
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Glutamine Maintains Satellite Glial Cells Growth and Survival in Culture
Satellite glial cells (SGCs) tightly surround neurons and modulate sensory transmission in dorsal root ganglion (DRG). At present, the biological...
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Excess glutamine does not alter myotube metabolism or insulin sensitivity
Glutamine is an amino acid previously linked with improved skeletal muscle metabolism and insulin signaling, however, past observations often use...
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Cerium ions immobilized magnetic graphite nitride decorated with L-Alanyl-L-Glutamine as new chelator for enrichment of phosphopeptides
Cerium ions immobilized magnetic graphite nitride material have been prepared using L-Alanyl-L-Glutamine as the new chelator. The resulting Fe 3 O 4 /g-C 3 N...
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Effect of glutamine on the systemic innate immune response in broiler chickens challenged with Salmonella pullorum
BackgroundThe objective of this study was to evaluate the effects of glutamine on the growth performance and systemic innate immune response in...
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Proof of stability of an RSV Controlled Human Infection Model challenge agent
In 2018, SGS Belgium NV developed RSV-NICA (Respiratory Syncytial Virus-Nasobronchial Infective Challenge Agent), an RSV type A challenge agent for...
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Bioinformatics and machine learning were used to validate glutamine metabolism-related genes and immunotherapy in osteoporosis patients
BackgroundOsteoporosis (OP), often referred to as the “silent disease of the twenty-first century,” poses a significant public health concern due to...
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Targeting glutamine metabolism network for the treatment of therapy-resistant prostate cancer
Advanced and aggressive prostate cancer (PCa) depends on glutamine for survival and proliferation. We have previously shown that inhibition of...
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Glutamine Metabolism in Cancer
Metabolism is a fundamental process for all cellular functions. For decades, there has been growing evidence of a relationship between metabolism and...