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Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma
There is a critical need to identify new therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Transcriptional co-regulators...
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Oncogenes, Signal Transduction and the Hallmarks of Cancer
In this chapter, we will understand that the observation that RNA tumor viruses can transform normal cells into cancer cells led to the discovery of...
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Promotion of stem cell-like phenotype of lung adenocarcinoma by FAM83A via stabilization of ErbB2
Lung cancer stands as the leading cause of mortality among all types of tumors, with over 40% of cases being lung adenocarcinoma (LUAD). Family with...
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ERBB2 Targeting Reveals a Significant Suppression of Tumorigenesis in Murine Endometrial Cancer with Pten Mutation
Endometrial cancer is the most common gynecologic malignancy. PTEN is a negative regulator of PI3K signaling and is deficient in > 50% of primary...
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Tumor Progression through Interaction of Mucins with Lectins and Subsequent Signal Transduction
Glycans bearing on cell surface glycoproteins are often altered in tumor cells. A variety of aberrant glycans, tumor-associated carbohydrate...
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Metformin alleviates ethanol-induced cardiomyocyte injury by activating AKT/Nrf2 signaling in an ErbB2-dependent manner
BackgroundMetformin, a first-line oral anti-diabetic drug, has recently been reported to exert protective effect on various cardiovascular diseases....
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Oncogenes and Signal Transduction
The observation that RNA tumor viruses, which have captured host genes encoding for key proteins in signal transduction cascades, can transform...
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Multivalent adaptor proteins specifically target NK cells carrying a universal chimeric antigen receptor to ErbB2 (HER2)-expressing cancers
Chimeric antigen receptor (CAR)-engineered immune effector cells constitute a promising approach for adoptive cancer immunotherapy. Nevertheless,...
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Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy
The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits,...
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Glycosylation promotes the cancer regulator EGFR-ErbB2 heterodimer formation — molecular dynamics study
ErbB family of receptor tyrosine kinases play significant roles in cellular differentiation and proliferation. Mutation or overexpression of these...
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Integrated approach to functional analysis of an ERBB2 variant of unknown significance detected by a cancer gene panel test
PurposeDealing with variants of unknown significance (VUS) is an important issue in the clinical application of NGS-based cancer gene panel tests. We...
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Nuclear ErbB2 represses DEPTOR transcription to inhibit autophagy in breast cancer cells
ErbB2, a classical receptor tyrosine kinase, is frequently overexpressed in breast cancer cells. Although the role of ErbB2 in the transmission of...
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Signal Transducer and Activator of Transcription as a Potential Therapeutic Target in Breast Cancer
Signal transducer and activator of transcription (STAT) signaling pathway, connected upstream with Janus kinases (JAK) proteins, is known to be...
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Record the Single Cell Signal Pathway
Systems biology promises to deliver a holistic time and space understanding of biological processes with applications including the identification of...
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Epiregulin confers EGFR-TKI resistance via EGFR/ErbB2 heterodimer in non-small cell lung cancer
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective against non-small cell lung cancer (NSCLC) with EGFR -activating...
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Ag nanorod@PEI-Ag nanohybrid as an excellent signal label for sensitive and rapid detection of serum HER2
The accurate detection of Human epidermal growth factor receptor-2 (HER2) as a critical breast cancer biomarker can be essential for the early...
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Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of squalene against inflammation
Squalene (SQ) has been documented in the past for its ability to reduce inflammation, but its mechanism needs more information. In this study, we...
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Oncoinformatic screening of the gene clusters involved in the HER2-positive breast cancer formation along with the in silico pharmacodynamic profiling of selective long-chain omega-3 fatty acids as the metastatic antagonists
AbstractThe HER2-positive patients occupy ~ 30% of the total breast cancer patients globally where no prevalent drugs are available to mitigate the...
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Conformational diversity and protein–protein interfaces in drug repurposing in Ras signaling pathway
We focus on drug repurposing in the Ras signaling pathway, considering structural similarities of protein–protein interfaces. The interfaces formed...
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Epithelial–Mesenchymal Transition and Cancer Stem Cells
Epithelial–mesenchymal transition (EMT), a cellular phenotypic change from epithelial to mesenchymal-like features, is related to the resistance and...