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Germline VWF/MPRIP and somatoplasm FGA variants synergically confer susceptibility to non-traumatic osteonecrosis of the femoral head
Non-traumatic osteonecrosis of the femoral head (ONFH) relies on multiple pathogenic factors, including intravascular coagulation, osteoporosis and...
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Staphylococcus aureus vWF-binding protein triggers a strong interaction between clum** factor A and host vWF
The Staphylococcus aureus cell wall-anchored adhesin ClfA binds to the very large blood circulating protein, von Willebrand factor (vWF) via...
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The disulfide bond Cys2724-Cys2774 in the C-terminal cystine knot domain of von Willebrand factor is critical for its dimerization and secretion
BackgroundType 3 von Willebrand disease (VWD) exhibits severe hemorrhagic tendency with complicated pathogenesis. The C-terminal cystine knot (CTCK)...
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von Willebrand Disease: An Update on Diagnosis and Treatment
von Willebrand disease (VWD) is the most common congenital bleeding disorder with a potential incidence of 1% of the general population. The disorder...
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Population-based prevalence and mutational landscape of von Willebrand disease using large-scale genetic databases
Von Willebrand disease (VWD) is a common bleeding disorder caused by mutations in the von Willebrand factor gene ( VWF ). The true global prevalence of...
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Von Willebrand Factor and Platelet Aggregation: from Bench to Clinical Practice
Purpose of ReviewThis review describes von Willebrand factor (VWF)-mediated platelet function in inherited and acquired bleeding disorders, and...
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Spire1 and Myosin Vc promote Ca2+-evoked externalization of von Willebrand factor in endothelial cells
Weibel–Palade bodies (WPB) are endothelial cell-specific storage granules that regulate vascular hemostasis by releasing the platelet adhesion...
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Von Willebrand Factor in Health and Disease
Abstract —Von Willebrand factor (vWF), the key component of hemostasis, is synthesized in endothelial cells and megakaryocytes and released into the...
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Staphylococcus aureus iron-regulated surface determinant B (IsdB) protein interacts with von Willebrand factor and promotes adherence to endothelial cells
Staphylococcus aureus is the cause of a spectrum of diseases in humans and animals. The molecular basis of this pathogenicity lies in the expression...
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Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor
Von Willebrand disease (VWD), the most common inherited bleeding disorder in humans, is caused by quantitative or qualitative defects in von...
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Physiological Roles of the von Willebrand Factor-Factor VIII Interaction
Von Willebrand factorVon Willebrand Factor (VWF) (VWF) and coagulationCoagulation factorCoagulation factor VIII (FVIII) VIII (FVIII) circulate as a...
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Antithrombotic Therapy for ECMO
Over the last decade, the use of extracorporeal devices for the management of critically ill patients has increased tremendously. However significant...
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SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity
Cerebrospinal fluid is a clear fluid that occupies the ventricular and subarachnoid spaces within and around the brain and spinal cord. Cerebrospinal...
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Classification and Management of Type 1 von Willebrand Disease
Von Willebrand disease (VWD) is a defect of the primary hemostatic pathway that results from quantitative or qualitative deficiencies of the von...
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Engineered Molecular Therapeutics Targeting Fibrin and the Coagulation System: a Biophysical Perspective
The coagulation cascade represents a sophisticated and highly choreographed series of molecular events taking place in the blood with important...
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Presentation and Management of Type 2 von Willebrand Disease
Type 2 von Willebrand disease (VWD) is caused by qualitative defects of von Willebrand factor (VWF). It is further divided into four subtypes (2A,...
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Development and classification of RNA aptamers for therapeutic purposes: an updated review with emphasis on cancer
Today, RNA aptamers are being considered promising theranostic tools against a wide variety of disorders. RNA aptamers can fold into complex shapes...
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Traumatic Brain Injury-Induced Coagulopathy
Coagulopathy after traumatic brain injury is frequent and predicts poor clinical outcomes for the patients. Despite their similar clinical...
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von Willebrand Disease
von Willebrand disease (VWD) is the most prevalent bleeding disorder. A detailed evaluation of personal and family history of bleeding can help...
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Molecular and clinical profile of type 2 von Willebrand disease in Iran: a thirteen-year experience
Type 2 von Willebrand disease (VWD) is the most common congenital bleeding disorder, with variable bleeding tendency and a complex laboratory...
