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Reactive Type II Pneumocyte Hyperplasia Versus Adenocarcinoma
Reactive type II pneumocyte hyperplasia is a nonspecific reactive proliferation of type II pneumocytes in response to a variety of lung injuries and...
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Multifocal micronodular pneumocyte hyperplasia lacking typical clinical features of the tuberous sclerosis complex: a case report and literature review
BackgroundMultifocal micronodular pneumocyte hyperplasia (MMPH) is a rare pulmonary manifestation of the tuberous sclerosis complex (TSC) with...
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Ferroptosis and pyroptosis signatures in critical COVID-19 patients
Critical COVID-19 patients admitted to the intensive care unit (ICU) frequently suffer from severe multiple organ dysfunction with underlying...
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P. aeruginosa type III and type VI secretion systems modulate early response gene expression in type II pneumocytes in vitro
BackgroundLung airway epithelial cells are part of innate immunity and the frontline of defense against bacterial infections. During infection,...
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Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death
Alveolar macrophages (AM) hold lung homeostasis intact. In addition to the defense against inhaled pathogens and deleterious inflammation, AM also...
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Efficacy of COVID-HIGIV in animal models of SARS-CoV-2 infection
In late 2019 the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus emerged in China and quickly spread into a worldwide pandemic. It...
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H1N1 Influenza in Pregnancy: Yet Another Dreaded Flu
The maternal immune system is already burdened with providing a supportive molecular environment to the develo** genetically foreign fetus....
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The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019
BackgroundThe coronavirus disease 2019 (COVID-19) has induced a worldwide epidemiological event with a high infectivity and mortality. However, the...
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The possible effects of α-tocopherol against amiodarone-treated lungs in rats: vimentin detection, lipid peroxidation assay, and histological and ultrastructural evaluations
The purpose of this study was to learn more about the pathogenesis of amiodarone (AD) on alveoli and also the possible preventive effect of...
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Ultrastructural study confirms the formation of single and heterotypic syncytial cells in bronchoalveolar fluids of COVID-19 patients
BackgroundSARS-CoV-2 was reported to induce cell fusions to form multinuclear syncytia that might facilitate viral replication, dissemination, immune...
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COVID-19 autopsies of Istanbul
Background/aimsThe aim of this study is to share autopsy findings of COVID-19-positive cases and autopsy algorithms for safely handling of suspicious...
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Autopsy findings of pediatric COVID-19: a systematic review
BackgroundLittle is known how COVID-19 is affecting children. Autopsies help gain an understanding of the pathophysiology of new and develo**...
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COVID-19 Vasculitis and vasculopathy-Distinct immunopathology emerging from the close juxtaposition of Type II Pneumocytes and Pulmonary Endothelial Cells
The SARS-CoV-2 virus ACE-2 receptor utilization for cellular entry and the defined ACE-2 receptor role in cardiovascular medicine hinted at...
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Mechanics of Lung Development
We summarize how skeletal muscle and lung developmental biology fields have been bridged to benefit from mouse genetic engineering technologies and...
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MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge
Numerous vaccine candidates against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are under development. The majority of vaccine...
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Potential protective effect of 3,3′-methylenebis(1-ethyl-4-hydroxyquinolin-2(1H)-one) against bleomycin-induced lung injury in male albino rat via modulation of Nrf2 pathway: biochemical, histological, and immunohistochemical study
Acute lung injury is a serious condition accounting for the majority of acute respiratory failure. Bleomycin (BLM) is an antibiotic that was first...
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Combination of losartan with pirfenidone: a protective anti-fibrotic against pulmonary fibrosis induced by bleomycin in rats
Pirfenidone (PFD), one acceptable medication for treating idiopathic pulmonary fibrosis (IPF), is not well tolerated by patients at full doses....
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Quercetin ameliorates acute lung injury in a rat model of hepatopulmonary syndrome
BackgroundCommon bile duct ligation (BDL) is a rat experimental model to induce biliary cirrhosis. Lung fibrosis and pulmonary vascular angiogenesis...
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A mammalian lung's immune system minimizes tissue damage by initiating five major sequential phases of defense
The mammalian lungs encounter several pathogens, but have a sophisticated multi-phase immune defense. Furthermore, several immune responses to...
