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The biological function of tumor-derived extracellular vesicles on metabolism
Multiple studies have shown that extracellular vesicles (EVs) play a key role in the process of information transfer and material transport between...
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Amino acid metabolism in tumor biology and therapy
Amino acid metabolism plays important roles in tumor biology and tumor therapy. Accumulating evidence has shown that amino acids contribute to...
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Tumor Metabolism: Challenges and Future Perspectives
Cancer can be characterized as a set of more than 200 diseases that have in common the capacity for disordered growth and increased invasive...
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Sphingolipid Metabolism in Tumor Cells
AbstractSphingolipids are a diverse family of complex lipids typically composed of a sphingoid base bound to a fatty acid via amide bond. The...
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RNA Modifications in Cancer Metabolism and Tumor Microenvironment
RNA modifications have recently been recognized as essential posttranscriptional regulators of gene expression in eukaryotes. Investigations over the...
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m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism
Glycolytic reprogramming is one of the most important features of cancer and plays an integral role in the progression of cancer. In cancer cells,...
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TAB182 regulates glycolytic metabolism by controlling LDHA transcription to impact tumor radiosensitivity
Metabolic reprogramming, a hallmark of cancer, is closely associated with tumor development and progression. Changes in glycolysis play a crucial...
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Targeting metabolism to enhance immunotherapy within tumor microenvironment
Cancer metabolic reprogramming has been considered an emerging hallmark in tumorigenesis and the antitumor immune response. Like cancer cells, immune...
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Identification and Validation of Lipid Metabolism Gene FASN-Associated miRNA in Wilms Tumor
miRNA has been a research hotspot in recent years and its scope of action is very wide, involving the regulation of cell proliferation,...
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Deciphering glutamine metabolism patterns for malignancy and tumor microenvironment in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer characterized by metabolic reprogramming. Glutamine metabolism is...
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AMPK–a key factor in crosstalk between tumor cell energy metabolism and immune microenvironment?
Immunotherapy has now garnered significant attention as an essential component in cancer therapy during this new era. However, due to immune...
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Physical Regulations of Cell Interactions and Metabolism in Tumor Microenvironments
Despite the advances in cancer therapeutics over the recent years, cancer remains the second leading cause of death in the United States, with...
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Machine learning survival prediction using tumor lipid metabolism genes for osteosarcoma
Osteosarcoma is a primary malignant tumor that commonly affects children and adolescents, with a poor prognosis. The existence of tumor heterogeneity...
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Targeting dysregulated lipid metabolism in the tumor microenvironment
The reprogramming of lipid metabolism and its association with oncogenic signaling pathways within the tumor microenvironment (TME) have emerged as...
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Lipid metabolism reprogramming in tumor-associated macrophages and implications for therapy
The tumormicroenvironment (TME) plays a key role in tumor progression. Tumor-associated macrophages (TAMs), which are natural immune cells abundantin...
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Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity
Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging...
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TBC1D5 reverses the capability of HIF-2α in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy
BackgroundClear cell renal cell carcinoma (ccRCC) is known for abnormal lipid metabolism and widespread activation of HIF-2α. Recently, the...
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Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets
Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular...
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Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism
Glycolytic reprogramming is emerging as a hallmark of various cancers and a promising therapeutic target. Nanotechnology is revolutionizing the...
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Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer
Tumors are intrinsically heterogeneous and it is well established that this directs their evolution, hinders their classification and frustrates...
