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Triptolide attenuates irritable bowel syndrome via inhibiting ODC1
BackgroundIrritable bowel syndrome (IBS) is a chronic disorder of the gut-brain axis with significant morbidity. Triptolide, an active compound...
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Triptolide regulates the balance of Tfr/Tfh in lupus mice
Introduction/objectivesSystemic lupus erythematosus (SLE) is a classic prototype of the multisystem autoimmune disease and follows a relapsing and...
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Let-7b-5p promotes triptolide-induced growth-inhibiting effects in glioma by targeting IGF1R
Glioma is one of the most common malignancies of the central nervous system. The therapeutic effect has not been satisfactory despite advances in...
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Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer
Paclitaxel resistance is associated with a poor prognosis in non-small cell lung cancer (NSCLC) patients, and currently, there is no promising drug...
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Triptolide activates the Nrf2 signaling pathway and inhibits the NF-κB signaling pathway to improve Alzheimer disease
Alzheimer disease (AD) is a common neurodegenerative disease with pathological features of accumulated amyloid plaques, neurofibrillary tangles, and...
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Antitumor mechanisms and future clinical applications of the natural product triptolide
Triptolide (TPL) is a compound sourced from Tripterygium wilfordii Hook. F., a traditional Chinese medicinal herb recognized for its impressive...
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Glycosylated triptolide affords a potent in vivo therapeutic activity to hepatocellular carcinoma in mouse model
While studies have demonstrated the therapeutic potential of triptolide for different cancers including hepatocellular carcinoma (HCC), its...
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Triptolide induces PANoptosis in macrophages and causes organ injury in mice
Macrophages represent the first lines of innate defense against pathogenic infections and are poised to undergo multiple forms of regulated cell...
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Triptolide mitigates the inhibition of osteogenesis induced by TNF-α in human periodontal ligament stem cells via the p-IκBα/NF-κB signaling pathway: an in-vitro study
BackgroundTriptolide is a widely utilized natural anti-inflammatory drug in clinical practice. Aim of this study was to evaluate effects of...
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Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae
Triptolide is a valuable multipotent antitumor diterpenoid in Tripterygium wilfordii , and its C-14 hydroxyl group is often selected for modification...
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Transcriptional expression of CXCL10 and STAT1 in lupus nephritis and the intervention effect of triptolide
ObjectiveThis study screened out the key genes associated with the occurrence and development of lupus nephritis (LN) using bioinformatics methods,...
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Therapeutic synergy of Triptolide and MDM2 inhibitor against acute myeloid leukemia through modulation of p53-dependent and -independent pathways
Dysregulation of MDM2, a p53 negative regulator, frequently occurs in acute myeloid leukemia (AML) and is associated with unfavorable prognoses,...
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Novel pH-sensitive triptolide-loaded micelles: a potential approach to increase anti-tumor activity of the diterpenoid epoxide
Tripterygium wilfordii Hook F, a traditional medicine in China has bioactive but toxic triptolide (TP, a diterpenoid triepoxide) as its main active...
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Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity
With the increasing epidemiology of autoimmune disease worldwide, there is an urgent need for effective drugs with low cost in clinical treatment....
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Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine
As a natural product with various biological activities, triptolide (TP) has been reported in anti-inflammatory, anti-tumor and anti-autoimmune...
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Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma
Immunotherapy has good potential to eradicate tumors in the long term. However, due to the low immunogenicity of tumor cells, current cancer...
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Network pharmacology of triptolide in cancer cells: implications for transcription factor binding
Background Triptolide is an active natural product, which inhibits cell proliferation, induces cell apoptosis, suppresses tumor metastasis and...
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Triptolide Alleviates Podocyte Epithelial-Mesenchymal Transition via Kindlin-2 and EMT-Related TGF-β/Smad Signaling Pathway in Diabetic Kidney Disease
Diabetes-induced chronic kidney diseases are widespread and decrease the quality of life for millions of affected individuals in China. To date, no...
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Triptolide protects against white matter injury induced by chronic cerebral hypoperfusion in mice
White matter injury is the major pathological alteration of subcortical ischemic vascular dementia (SIVD) caused by chronic cerebral hypoperfusion....
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Triptolide with hepatotoxicity and nephrotoxicity used in local delivery treatment of myocardial infarction by thermosensitive hydrogel
Myocardial infarction (MI) resulting from coronary artery occlusion is the leading global cause of cardiovascular disability and mortality....
