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Serum biomarkers for Modic changes in patients with chronic low back pain
PurposeLumbar Modic change (MC) can serve as a diagnostic marker as well as an independent source of chronic low back pain (CLBP). This study aimed...
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Renin Angiotensin System in the Maturation and Failure of Arterio-Venous Fistula
An arteriovenous fistulaArteriovenous fistula (AVF) is the most used vascular access for hemodialysis but is associated with failure occurring within...
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Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model
Triple-negative breast cancer (TNBC) is highly aggressive with limited available treatments. Stromal cells in the tumor microenvironment (TME) are...
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VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane
Vascular endothelial cells (VECs) are key players in the formation of neovessels and tumor metastasis, the ultimate cause of the majority of...
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Integrating traditional ecological knowledge into habitat restoration: implications for meeting forest restoration challenges
BackgroundTraditional ecological knowledge (TEK) helps tribal communities adapt to socio-ecological changes, improving the long-term sustainability...
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Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models
Alzheimer’s disease (AD) is an age-related disease, with loss of integrity of the blood–brain barrier (BBB) being an early feature. Cellular...
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Evidence-Based and Clinical Experimentation on Cell Therapy
Several local and systemic conditions could lead to chronic ulcers. Remarkable improvements have been made in wound dressing technologies in the last...
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VCAM-1 complements CA-125 in detecting recurrent ovarian cancer
BackgroundClose to three-quarters of ovarian cancer cases are frequently diagnosed at an advanced stage, with more than 70% of them failing to...
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Multi-omics analysis revealed TEK and AXIN2 are potential biomarkers in multifocal papillary thyroid cancer
BackgroundPapillary thyroid carcinoma (PTC), the most common endocrine cancer, accounts for 80–85% of all malignant thyroid tumors. This study...
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The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium
Leukocytes and resident cells in the arterial wall contribute to atherosclerosis, especially at sites of disturbed blood flow. Expression of...
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PIK3CA mutation correlates with mTOR pathway expression but not clinical and pathological features in Fibro-adipose vascular anomaly (FAVA)
BackgroundFibro-adipose vascular anomaly (FAVA) is a rare and new entity of vascular anomaly. Activating mutations in the phosphatidylinositol-4,5-bis...
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Knowledge in motion: temporal dynamics of wild food plant use in the Polish-Lithuanian-Belarusian border region
BackgroundUnderstanding how Local Ecological Knowledge (LEK) evolves over time is crucial for fostering social and environmental responsibility. This...
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Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function
AimsLong-COVID occurs after SARS-CoV-2 infection and results in diverse, prolonged symptoms. The present study aimed to unveil potential mechanisms,...
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Contemporary management of extracranial vascular malformations
Vascular malformations are congenital vascular anomalies that originate because of disorganized angiogenesis, most commonly from spontaneous somatic...
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Environmental aluminum oxide inducing neurodegeneration in human neurovascular unit with immunity
Aluminum oxide nanoparticle (AlNP), a ubiquitous neurotoxin highly enriched in air pollution, is often produced as an inevitable byproduct in the...
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Endothelial Cell–Matrix Interactions in Angiogenesis and Vessel Homeostasis: A Focus on Laminins and Their Integrin Receptors
Integrin-mediated interaction of cells with proteins present in the extracellular matrix and basement membranes direct many cellular processes...
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Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis
Lymphangiogenesis is an essential physiological process but also a determining factor in vascular-related pathological conditions. Angiopoietin-2...
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Multi-omics analysis of macrophage-associated receptor and ligand reveals a strong prognostic signature and subtypes in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a significant contributor to morbidity and mortality worldwide. The interaction between receptors and ligands is...
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Metabolic dependency of non-small cell lung cancer cells affected by three-dimensional scaffold and its stiffness
Three-dimensional (3D) extracellular matrix (ECM) microenvironment is an important regulator of the stiffness of the tumors. Cancer cells require...
