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Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq
Thymic T cell development comprises T cell receptor (TCR) recombination and assessment of TCR avidity towards self-peptide-MHC complexes presented by...
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Spatiotemporal commonality of the TCR repertoire in a T-cell memory murine model and in metastatic human colorectal cancer
Immune checkpoint inhibitors (ICIs) have shown superior clinical responses and significantly prolong overall survival (OS) for many types of cancer....
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The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression
The regulation of thymocyte development by RNA-binding proteins (RBPs) is largely unexplored. We identify 642 RBPs in the thymus and focus on Arpp21,...
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Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage
BackgroundThe current pandemic of coronavirus disease 2019 (COVID-19), transmitted person-to-person by the severe acute respiratory syndrome of...
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Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis)
BackgroundCynomolgus macaque ( Macaca fascicularis ) is an attractive animal model for the study of human disease and is extensively used in...
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TCR repertoire landscape reveals macrophage-mediated clone deletion in endotoxin tolerance
BackgroundEndotoxin tolerance (ET) is a protective mechanism in the process of sepsis, septic shock, and their sequelae including uncontrolled...
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Composition and diversity analysis of the TCR CDR3 repertoire in patients with idiopathic orbital inflammation using high-throughput sequencing
BackgroundIdiopathic orbital inflammation (IOI) is a nonspecific orbital inflammatory disease with the third highest prevalence among orbital...
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TCR-L: an analysis tool for evaluating the association between the T-cell receptor repertoire and clinical phenotypes
BackgroundT cell receptors (TCRs) play critical roles in adaptive immune responses, and recent advances in genome technology have made it possible to...
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Radiotherapy-activated NBTXR3 nanoparticles modulate cancer cell immunogenicity and TCR repertoire
BackgroundRadiotherapy is a powerful and widely used technique for the treatment of solid tumors. Beyond its ability to destroy tumor cells, it has...
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Characterization of T cell receptor repertoire in penile cancer
Tumor-infiltrating lymphocytes (TILs) play a key role in regulating the host immune response and sha** tumor microenvironment. It has been...
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Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals
SARS-CoV-2 outbreak has been declared by World Health Organization as a worldwide pandemic. However, there are many unknowns about the...
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Potential of TCR sequencing in graft-versus-host disease
Graft-versus-host disease (GvHD) remains one of the major complications following allogeneic haematopoietic stem cell transplantation (allo-HSCT)....
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scRNA-seq revealed the special TCR β & α V(D)J allelic inclusion rearrangement and the high proportion dual (or more) TCR-expressing cells
Allelic exclusion, one lymphocyte expresses one antigen receptor, is a fundamental mechanism of immunological self-tolerance and highly specific...
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Germline-enforced enrichment for charged amino acids in TCR beta chain (TCRβ) complementarity determining region 3 (CDR-B3) alters T cell development, repertoire content, and antigen recognition
T cell receptor beta chain (TCRβ) diversity (Dβ) gene segments are highly conserved across evolution, with trout Dβ1 sequence identical to human and...
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Profiling of T cell repertoire in peripheral blood of patients from type 2 diabetes with complication
PurposeMore than 90% of patients with diabetes worldwide are type 2 diabetes (T2D), which is caused by insulin resistance or impaired producing...
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GIANA allows computationally-efficient TCR clustering and multi-disease repertoire classification by isometric transformation
Similarity in T-cell receptor (TCR) sequences implies shared antigen specificity between receptors, and could be used to discover novel therapeutic...
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Assessment of the TCR Repertoire of Human Circulating T Follicular Helper Cells
Every T cell clone has its unique T cell receptor that results from somatic recombination of V(D)J genes in develo** T cells. This process leads to...
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T-Cell Repertoire Characterization
This volume provides a comprehensive compilation of protocols in T cell repertoire analysis, from the leading experts in the field, representing both...
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Characterization of T-Cell receptor repertoire in immunoglobulin a nephropathy
Immunoglobulin A nephropathy (IgAN) is an autoimmune disease characterized by abnormal IgA deposition in glomerulus. Current diagnosis of IgAN still...
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Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severity
T cell receptor (TCR) repertoires are critical for antiviral immunity. Determining the TCR repertoire composition, diversity, and dynamics and how...
