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Analyzing immune responses to varied mRNA and protein vaccine sequences
In response to the COVID-19 pandemic, different types of vaccines, such as inactive, live-attenuated, messenger RNA (mRNA), and protein subunit, have...
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Combination Ad26.RSV.preF/preF protein vaccine induces superior protective immunity compared with individual vaccine components in preclinical models
Respiratory syncytial virus (RSV) is a leading cause of severe respiratory disease for which no licensed vaccine is available. We have previously...
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Immunogenicity and protection efficacy of a COVID-19 DNA vaccine encoding spike protein with D614G mutation and optimization of large-scale DNA vaccine production
Severe acute respiratory syndrome coronavirus 2 had devastating consequences for human health. Despite the introduction of several vaccines, COVID-19...
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Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein
The Paramyxoviridae family encompasses medically significant RNA viruses, including human respiroviruses 1 and 3 (RV1, RV3), and zoonotic pathogens...
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Immunogenicity of the DNA/Protein Combined Vaccine against COVID-19
During the COVID-19 pandemic, the development of prophylactic vaccines, including those based on new platforms, became highly relevant. One such...
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Prophylactic Hepatitis E Vaccine
The hepatitis E has been increasingly recognized as an underestimated global disease burden in recent years. Subpopulations with more serious...
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Long-term trial of protection provided by adenovirus-vectored vaccine expressing the PPRV H protein
A recombinant, replication-defective, adenovirus-vectored vaccine expressing the H surface glycoprotein of peste des petits ruminants virus (PPRV)...
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Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents
Respiratory syncytial virus (RSV) is a leading cause of upper and lower respiratory tract infection, especially in children and the elderly. Various...
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In-depth characterization of protein N-glycosylation for a COVID-19 variant-design vaccine spike protein
COVID-19 is caused by SARS-CoV-2 infection and remains one of the biggest pandemics around the world since 2019. Vaccination has proved to be an...
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The CDE region of feline Calicivirus VP1 protein is a potential candidate subunit vaccine
BackgroundFeline calicivirus (FCV) infection causes severe upper respiratory disease in cats, but there are no effective vaccines available for...
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Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine
The 2002 SARS outbreak, the 2019 emergence of COVID-19, and the continuing evolution of immune-evading SARS-CoV-2 variants together highlight the...
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Plant Molecular Farming for Vaccine Development
Vaccines are effective tools for the prophylaxis of infectious diseases. Various diseases have been eradicated using vaccines, and the importance of...
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In Silico Structure-Based Vaccine Design
Structure-based vaccine design (SBVD) is an important technique in computational vaccine design that uses structural information on a targeted...
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Exosome-Based COVID-19 Vaccine
Extracellular vesicles (EVs) enable cell-to-cell communication and, by delivering antigens, can stimulate the immune response strongly. Approved in...
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Computer-Aided Multi-Epitope Based Vaccine Design Against Monkeypox Virus Surface Protein A30L: An Immunoinformatics Approach
Monkeypox, a viral zoonotic disease resembling smallpox, has emerged as a significant national epidemic primarily in Africa. Nevertheless, the recent...
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Safety and immunogenicity of a recombinant protein RBD fusion heterodimer vaccine against SARS-CoV-2
In response to COVID-19 pandemic, we have launched a vaccine development program against SARS-CoV-2. Here we report the safety, tolerability, and...
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Design of a novel multiepitope vaccine against Chlamydia pneumoniae using the extracellular protein as a target
Chlamydia pneumoniae ( C. pneumoniae ) infection in humans is universal and causes various respiratory infectious diseases, making a safe and effective...
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Immunoinformatics design of novel multi-epitope vaccine against Trueperella Pyogenes using collagen adhesion protein, fimbriae, and pyolysin
Trueperella pyogenes ( T. pyogenes ) is an opportunistic pathogen that causes infertility, mastitis, and metritis in animals. T. pyogenes is also a...
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Developmental and reproductive toxicity of a recombinant protein subunit COVID-19 vaccine (ZF2001) in rats
ZF2001, a protein subunit vaccine against coronavirus disease 2019 (COVID-19), contains recombinant tandem repeat of dimeric receptor-binding domain...
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Safety and immunogenicity of a tetravalent and bivalent SARS-CoV-2 protein booster vaccine in men
The safety and immunogenicity of a protein-based tetravalent vaccine SCTV01E that contains spike protein ectodomain (S-ECD) of Alpha, Beta, Delta and...
