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Maternal tamoxifen exposure leads to abnormal primordial follicle assembly
Tamoxifen (TAM) is an accredited drug used for treatment and prevention of breast cancer. Due to the long-term taking and the trend for women to...
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Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development
BackgroundCircRNAs are a class of noncoding RNAs with tissue- and development-specific expression characteristics. In many mammals, primordial...
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SRSF1 regulates primordial follicle formation and number determination during meiotic prophase I
BackgroundOvarian folliculogenesis is a tightly regulated process leading to the formation of functional oocytes and involving successive quality...
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Maternal vitamin B1 is a determinant for the fate of primordial follicle formation in offspring
The mediation of maternal-embryonic cross-talk via nutrition and metabolism impacts greatly on offspring health. However, the underlying key...
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Impaired primordial follicle assembly in offspring ovaries from zearalenone-exposed mothers involves reduced mitochondrial activity and altered epigenetics in oocytes
Previous works have shown that zearalenone (ZEA), as an estrogenic pollutant, has adverse effects on mammalian folliculogenesis. In the present...
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HDAC6 regulates primordial follicle activation through mTOR signaling pathway
Primordial follicle pool established perinatally is a non-renewable resource which determines the female fecundity in mammals. While the majority of...
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The Reproductive Lifespan of Ovarian Follicle
The functional unit within mammalian ovaries is the ovarian follicle. The development of the ovarian follicle is a lengthy process beginning from the...
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Investigating the impact of vitrification on bovine ovarian tissue morphology, follicle survival, and transcriptomic signature
PurposeOvarian tissue cryopreservation is vital for fertility preservation, yet its effect on ovarian tissue follicle survival and transcriptomic...
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JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development
The number of embryonic primordial germ cells in Drosophila is determined by the quantity of germ plasm, whose assembly starts in the posterior...
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miR-378-3p maintains the size of mouse primordial follicle pool by regulating cell autophagy and apoptosis
Primordial follicle pool provides all available oocytes throughout the whole reproductive life span. Abnormal regulation in primordial follicle...
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Retention of higher fertility depending on ovarian follicle reserve in cystine-glutamate transporter gene-deficient mice
The cystine-glutamate transporter (xCT) is responsible for the transport of cystine into cells. We recently found that xCT-deficient (xCTKO) aged...
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Insights into in vivo follicle formation: a review of in vitro systems
In vitro systems capable of reconstituting the process of mouse oogenesis are now being established to help develop further understanding of the...
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Stem Cells in Adult Mice Ovaries Form Germ Cell Nests, Undergo Meiosis, Neo-oogenesis and Follicle Assembly on Regular Basis During Estrus Cycle
Very small embryonic-like (VSELs) and ovarian (OSCs) stem cells are located in adult mammalian ovary surface epithelium (OSE). OSCs can expand...
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Dynamic in vitro culture of bovine and human ovarian tissue enhances follicle progression and health
In vitro ovarian cortical tissue culture, followed by culture of isolated secondary follicles, is a promising future option for production of mature...
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Primordial germ cell DNA demethylation and development require DNA translesion synthesis
Mutations in DNA damage response (DDR) factors are associated with human infertility, which affects up to 15% of the population. The DDR is required...
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LSM14B controls oocyte mRNA storage and stability to ensure female fertility
Controlled mRNA storage and stability is essential for oocyte meiosis and early embryonic development. However, how to regulate mRNA storage and...
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High expression circRALGPS2 in atretic follicle induces chicken granulosa cell apoptosis and autophagy via encoding a new protein
BackgroundThe reproductive performance of chickens mainly depends on the development of follicles. Abnormal follicle development can lead to...
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Follicle inhibition at the primordial stage without increasing apoptosis, with a combination of everolimus, verapamil
The aim of the present study was to test whether inhibition of ovarian primordial follicles and subsequent activation can be achieved by transient...
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The Cellular and Molecular Mechanisms of Ovarian Aging
The initial primordial follicle pool size and the activation and depletion rates determine fertility potential. Generally, primordial follicles have...
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Primary oocytes with cellular senescence features are involved in ovarian aging in mice
In mammalian females, quiescent primordial follicles serve as the ovarian reserve and sustain normal ovarian function and egg production via...
