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Identification of RimR2 as a positive pathway-specific regulator of rimocidin biosynthesis in Streptomyces rimosus M527
BackgroundStreoptomyces rimosus M527 is a producer of the polyene macrolide rimocidin which shows activity against various plant pathogenic fungi....
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Regulator
The creation of an independent Regulator is an important step to ensuring the promotion and implementation of data laws within a country. This...
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Rule Design: Defining the Regulator–Regulatee Relationship
Rules constitute a defining feature of the relationship between regulators and regulated entities. To succeed in fostering sound risk management for...
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Engineering Streptomyces sp. CPCC 204095 for the targeted high-level production of isatropolone A by elucidating its pathway-specific regulatory mechanism
BackgroundIsatropolone A and C, produced by Streptomyces sp. CPCC 204095, belong to an unusual class of non-benzenoid aromatic compounds and contain...
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G2-LIKE CAROTENOID REGULATOR (SlGCR) is a positive regulator of lutein biosynthesis in tomato
Lutein is an oxygen-containing carotenoid synthesized in plant chloroplasts and chromoplasts. It plays an indispensable role in promoting plant...
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Transcriptomic and glycomic analyses highlight pathway-specific glycosylation alterations unique to Alzheimer’s disease
Glycosylation has been found to be altered in the brains of individuals with Alzheimer’s disease (AD). However, it is unknown which specific...
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A specific super-enhancer actuated by berberine regulates EGFR-mediated RAS–RAF1–MEK1/2–ERK1/2 pathway to induce nasopharyngeal carcinoma autophagy
Nasopharyngeal carcinoma (NPC), primarily found in the southern region of China, is a malignant tumor known for its highly metastatic...
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Fibulin2: a negative regulator of BMSC osteogenic differentiation in infected bone fracture healing
Bone fracture remains a common occurrence, with a population-weighted incidence of approximately 3.21 per 1000. In addition, approximately 2% to 50%...
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Ubiquitin-specific proteases in inflammatory bowel disease-related signalling pathway regulation
The exact pathogenesis of inflammatory bowel disease (IBD), a chronic gastrointestinal inflammatory disease comprising Crohn’s disease and ulcerative...
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Enhanced production of terrein in marine-derived Aspergillus terreus by refactoring both global and pathway-specific transcription factors
BackgroundTerrein, a major secondary metabolite from Aspergillus terreus , shows great potentials in biomedical and agricultural applications....
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Chromatin regulator SMARCAL1 modulates cellular lipid metabolism
Biallelic mutations of the chromatin regulator SMARCAL1 cause Schimke Immunoosseous Dysplasia (SIOD), characterized by severe growth defects and...
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Effect of kynurenic acid on enzymatic activity of the DNA base excision repair pathway in specific areas of the sheep brain
Relatively low levels of antioxidant enzymes coupled with high oxygen metabolism result in the formation of numerous oxidative DNA damages in the...
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The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice
Diabetic retinopathy (DR) is considered a primarily microvascular complication of diabetes. Müller glia cells are at the centre of the retinal...
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MilR3, a unique SARP family pleiotropic regulator in Streptomyces bingchenggensis
Streptomyces bingchenggensis is the main industrial producer of milbemycins, which are a group of 16-membered macrocylic lactones with excellent...
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Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors
BackgroundInactivation of the Hippo pathway promotes Yap nuclear translocation, enabling execution of a transcriptional program that induces tissue...
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Long Non-coding RNA X-Inactive Specific Transcript Promotes Esophageal Squamous Cell Carcinoma Progression via the MicroRNA 34a/Zinc Finger E-box–Binding Homeobox 1 Pathway
BackgroundThe long non-coding RNA X-inactive specific transcript (XIST) plays a crucial role in transcriptional silencing of the X chromosome. Zinc...
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Hmmr Acts as a Key Regulator in the ADSCs Proliferation and Mitosis
Obesity is a common chronic health problem that requires lifelong efforts for the successful treatment. The proliferation of ADSCs is an essential...
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Cell death dependent on holins LrgAB repressed by a novel ArsR family regulator CdsR
The cell death and survival paradox in various biological processes requires clarification. While spore development causes maternal cell death in Bacillus...
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A translational regulator MHZ9 modulates ethylene signaling in rice
Ethylene plays essential roles in rice growth, development and stress adaptation. Translational control of ethylene signaling remains unclear in...
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The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia
Dysregulated cholesterol homeostasis promotes tumorigenesis and progression. Therefore, metabolic reprogramming constitutes a new hallmark of cancer....
