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P300 Modulates Endothelial Mechanotransduction of Fluid Shear Stress
PurposeP300 is a lysine acetyltransferase that plays a significant role in regulating transcription and the nuclear acetylome. While P300 has been...
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p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth, metabolism and autophagy. Multiple pathways modulate...
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P300 in peripheral neuropathy: cognitive functions assessment and gender effect
BackgroundPatients with peripheral neuropathy (PN) have subtle central pathology that might contribute to cognitive impairment. P300 is a cognitive...
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P300 event-related potentials in patients with multiple sclerosis
BackgroundCognitive impairment (CI) is a common and disabling symptom during the disease even in the earliest “preclinical” phase of patients with MS...
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Epigenetic mechanisms to propagate histone acetylation by p300/CBP
Histone acetylation is important for the activation of gene transcription but little is known about its direct read/write mechanisms. Here, we report...
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The FreiBurger: a new optotype for P300-based acuity estimation
PurposeAccurate objective assessment of visual acuity is crucial, particularly in cases of suspected malingering, or when the patient’s inability to...
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TAZ2 truncation confers overactivation of p300 and cellular vulnerability to HDAC inhibition
The histone acetyltransferase p300/CBP is composed of several conserved domains, among which, the TAZ2 domain is known as a protein-protein...
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P300 Wave Alterations and Cognitive Impairment in Cerebellum Lesions
Patients with cognitive deficits have a prolonged latency and reduced amplitude of the P300 wave. However, no study has correlated P300 wave...
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Spatial Attention Effects on P300 BCI Performance: ERP and Eye-Tracking Study
AbstractP300 brain–computer interface (BCI), based on P300 (or P3) event-related potential component, is one of the first BCIs and has various...
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Cortical Generators and Connections Underlying Phoneme Perception: A Mismatch Negativity and P300 Investigation
The cortical generators of the pure tone MMN and P300 have been thoroughly studied. Their nature and interaction with respect to phoneme perception,...
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Upregulation of p300 in paclitaxel-resistant TNBC: implications for cell proliferation via the PCK1/AMPK axis
ObjectiveTo explore the role of p300 in the context of paclitaxel (PTX) resistance in triple-negative breast cancer (TNBC) cells, focusing on its...
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P300 event-related potentials in people with epilepsy: clinico-neurophysiologic study
BackgroundThere is increasing evidence that prolonged or recurrent seizures can cause or exacerbate cognitive impairment (CI) in memory, attention,...
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PAX3-FOXO1 uses its activation domain to recruit CBP/P300 and shape RNA Pol2 cluster distribution
Activation of oncogenic gene expression from long-range enhancers is initiated by the assembly of DNA-binding transcription factors (TF), leading to...
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Recent Advances in Clinical Applications of P300 and MMN
Event-related potentials (ERP), in particular P300 and MMN, have been used for decades in clinical research, but hardly in clinical practice. This...
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The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, fatal, fibrotic, interstitial lung disease of unknown cause. Despite extensive studies, the...
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Fatigue in children using motor imagery and P300 brain-computer interfaces
BackgroundBrain-computer interface (BCI) technology offers children with quadriplegic cerebral palsy unique opportunities for communication,...
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Targeting dependency on a paralog pair of CBP/p300 against de-repression of KREMEN2 in SMARCB1-deficient cancers
SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex, is the causative gene of rhabdoid tumors and epithelioid sarcomas. Here, we identify...
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Structural insights into p300 regulation and acetylation-dependent genome organisation
Histone modifications are deposited by chromatin modifying enzymes and read out by proteins that recognize the modified state. BRD4-NUT is an...
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Cognitive load associates prolonged P300 latency during target stimulus processing in individuals with mild cognitive impairment
Alterations in P300 amplitude and latency, as well as neuropsychological tests, are informative to detect early signs of the affected high cognitive...
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GR/P300 Regulates MKP1 Signaling Pathway and Mediates Depression-like Behavior in Prenatally Stressed Offspring
Accumulating evidence suggests that prenatal stress (PNS) increases offspring susceptibility to depression, but the underlying mechanisms remain...
