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Improving the catalytic characteristics of phenolic acid decarboxylase from Bacillus amyloliquefaciens by the engineering of N-terminus and C-terminus
Background4-vinylphenols produced by phenolic acid degradation catalyzed by phenolic acid decarboxylase can be used in food additives as well as...
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Significantly enhanced thermostability and inhibitory resistance of Aspergillus usamii xylanase by modifying its N-terminus and thumb regions
To improve the inhibitory insensitivity towards Aspergillus usamii E001 GH11F xylanase ( Au xyn11A) towards xylanase inhibitor protein (XIP-I), and Triti...
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The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus
The endogenous chemokines CCL19 and CCL21 signal via their common receptor CCR7. CCL21 is the main lymph node homing chemokine, but a weak...
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Truncation of the N-terminus of cardiac troponin I initiates adaptive remodeling of the myocardial proteosome via phosphorylation of mechano-sensitive signaling pathways
The cardiac isoform of troponin I has a unique N-terminal extension (~ 1–30 amino acids), which contributes to the modulation of cardiac contraction...
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SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site
SWI/SNF (BAF) chromatin remodelling complexes are key regulators of gene expression programs, and attractive drug targets for cancer therapies. Here...
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Nicotine Replacement Therapy
Tobacco smoking with its long history is of still high prevalence worldwide and has a high impact on human health and an enormous economic burden due...
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A single amino acid at position 31 in the N-terminus of the coat protein of cucumber mosaic virus determines its avirulence function for RCY1-conferred virus resistance
The coat protein (CP) of the cucumber mosaic virus (CMV) yellow strain [CMV(Y)], but not the CMV B2 strain [CMV(B2)], serves as an avirulence...
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Exploring the logic and conducting a comprehensive evaluation of AdipoRon-based adiponectin replacement therapy against hormone-related cancers—a systematic review
The potential benefits of adiponectin replacement therapy extend to numerous human diseases, with current research showing particular interest in its...
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Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression
Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. We here...
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Replacement of P1 of soybean mosaic virus with P1 of clover yellow vein virus has no impact on virus viability and host specificity
Potyvirus genomes are expressed as polyproteins that are autocatalytically cleaved to produce 10 to 12 multifunctional proteins, among which P1 is...
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A Nonsense N –Terminus NFKB2 Mutation Leading to Haploinsufficiency in a Patient with a Predominantly Antibody Deficiency
The noncanonical NF-κB pathway is implicated in diverse biological and immunological processes. Monoallelic C-terminus loss-of-function and...
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Cross-presentation of a TAP-independent signal peptide induces CD8 T immunity to escaped cancers but necessitates anchor replacement
Cancer cells frequently display defects in their antigen-processing pathway and thereby evade CD8 T cell immunity. We described a novel category of...
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Measurement of histone replacement dynamics with genetically encoded exchange timers in yeast
Histone exchange between histones carrying position-specific marks and histones bearing general marks is important for gene regulation, but...
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Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity
Seleno-insulin, a class of artificial insulin analogs, in which one of the three disulfide-bonds (S-S’s) of wild-type insulin (Ins) is replaced by a...
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Nicotine Replacement Therapy
Tobacco smoking with its long history is of still high prevalence worldwide and has a high impact on human health and an enormous economic burden due...
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Effect of prepropeptide replacement on γ-carboxylation and activity of recombinant coagulation factor IX
Based on observations indicating that the γ-carboxylase enzyme has a lower affinity for the protein C (PC) propeptide and that the γ-carboxylase...
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S92 phosphorylation induces structural changes in the N-terminus domain of human mitochondrial calcium uniporter
The mitochondrial calcium uniporter (MCU) plays essential roles in mitochondrial calcium homeostasis and regulates cellular functions, such as energy...
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Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex
Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory...
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Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern
Claudin-2 promotes breast cancer liver metastasis by enabling seeding and early cancer cell survival. We now demonstrate that Claudin-2 is...
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Contact Inhibition of Proliferation Is Accompanied by Expression of the PHF10D Subunit of the Chromatin Remodeling Complex PBAF in Mouse and Human Cell Lines
AbstractPHF10 is a subunit of the PBAF complex, which regulates the expression of many genes in develo** and maturing organisms. PHF10 has four...
