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Multicellular Organisms
The cell, as the backbone of life, is described in Sect. 1.13 . It is a standard unit of organization... -
Emergence and maintenance of stable coexistence during a long-term multicellular evolution experiment
The evolution of multicellular life spurred evolutionary radiations, fundamentally changing many of Earth’s ecosystems. Yet little is known about how...
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Genomes of multicellular algal sisters to land plants illuminate signaling network evolution
Zygnematophyceae are the algal sisters of land plants. Here we sequenced four genomes of filamentous Zygnematophyceae, including chromosome-scale...
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Microstructured soft devices for the growth and analysis of populations of homogenous multicellular tumor spheroids
Multicellular tumor spheroids are rapidly emerging as an improved in vitro model with respect to more traditional 2D culturing. Microwell culturing...
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Integrating Multicellular Systems: Physiological Control and Degrees of Biological Individuality
This paper focuses on physiological integration in multicellular systems, a notion often associated with biological individuality, but which has not...
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Modelling contractile ring formation and division to daughter cells for simulating proliferative multicellular dynamics
Cell proliferation is a fundamental process underlying embryogenesis, homeostasis, wound healing, and cancer. The process involves multiple events...
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Distinct types of multicellular aggregates in Pseudomonas aeruginosa liquid cultures
Pseudomonas aeruginosa forms suspended multicellular aggregates when cultured in liquid media. These aggregates may be important in disease, and/or...
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Subcellular localization of type IV pili regulates bacterial multicellular development
In mammals, subcellular protein localization of factors like planar cell polarity proteins is a key driver of the multicellular organization of...
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Crashworthiness analysis of double-corrugated multicellular tubes under axial impact
A new type of double circular corrugated multicellular tube was proposed, and its crashworthiness was analyzed under the same wall thickness. The...
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Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection
Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly...
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Programming multicellular assembly with synthetic cell adhesion molecules
Cell adhesion molecules are ubiquitous in multicellular organisms, specifying precise cell–cell interactions in processes as diverse as tissue...
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Biology System Description Language (BiSDL): a modeling language for the design of multicellular synthetic biological systems
BackgroundThe Biology System Description Language (BiSDL) is an accessible, easy-to-use computational language for multicellular synthetic biology....
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Collective curvature sensing and fluidity in three-dimensional multicellular systems
Collective cell migration is an essential process throughout the lives of multicellular organisms, for example in embryonic development, wound...
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4-bit adhesion logic enables universal multicellular interface patterning
Multicellular systems, from bacterial biofilms to human organs, form interfaces (or boundaries) between different cell collectives to spatially...
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Large-scale identification of genes involved in septal pore plugging in multicellular fungi
Multicellular filamentous fungi have septal pores that allow cytoplasmic exchange, and thus connectivity, between neighboring cells in the filament....
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Disconnecting multicellular networks in brain tumours
Cancer cells can organize and communicate in functional networks. Similarly to other networks in biology and sociology, these can be highly relevant...
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Multicellular communities are perturbed in the aging human brain and Alzheimer’s disease
The role of different cell types and their interactions in Alzheimer’s disease (AD) is a complex and open question. Here, we pursued this question by...
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NMR resonance assignment of the cell death execution domain BELL2 from multicellular bacterial signalosomes
Signalosomes are high-order protein machineries involved in complex mechanisms controlling regulated immune defense and cell death execution. The...
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Open-top multisample dual-view light-sheet microscope for live imaging of large multicellular systems
Multicellular systems grow over the course of weeks from single cells to tissues or even full organisms, making live imaging challenging. To bridge...