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Developmental validation of the STRSeqTyper122 kit for massively parallel sequencing of forensic STRs
Massively parallel sequencing allows for integrated genoty** of different types of forensic markers, which reduces DNA consumption, simplifies...
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The Challenges of Introducing Massively Parallel Sequencing into the UK Forensic Market
The introduction of any new forensic science technique into the Criminal Justice System requires extensive validation and accreditation as well as...
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Comparison of three massively parallel sequencing platforms for single nucleotide polymorphism (SNP) genoty** in forensic genetics
Three MPS platforms are being used in forensic genetic analysis, i.e., MiSeq FGx, Ion S5 XL, and MGISEQ-2000. However, few studies compared their...
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Variability of 27 Autosomal STR Loci for the Population of the Republic of Belarus Based on the Mass Parallel Sequencing Data
AbstractThe variability of 27 autosomal STR loci of the ForenSeq DNA Signature Prep Kit (Illumina) commercial panel was studied using the technique...
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A single-cell massively parallel reporter assay detects cell-type-specific gene regulation
Massively parallel reporter gene assays are key tools in regulatory genomics but cannot be used to identify cell-type-specific regulatory elements...
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Next-Generation Sequencing: ForenSeq™ DNA Signature Prep Kit with the Illumina MiSeq FGx
Sequencing forensic DNA samples that are amplified and prepared with the ForenSeq™ DNA Signature Prep Kit allows for the simultaneous targeting of...
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Comparison of tumor mutation burden of 300 various non-Hodgkin lymphomas using panel based massively parallel sequencing
BackgroundTumor mutation burden is an emerging biomarker for immunotherapy. Although several clinical trials for immunotherapy in lymphoma have been...
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Identification of 27 allele-specific regulatory variants in Parkinson’s disease using a massively parallel reporter assay
Genome wide association studies (GWAS) have identified a number of genomic loci that are associated with Parkinson’s disease (PD) risk. However, the...
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The First Autosomal STR Population Data of Kinh Ethinic Group in Vietnam by Using Massively Parallel Sequencing
AbstractApplications of massively parallel sequencing (MPS) in forensic genetics have allowed to exploit the true variation in core forensic STR...
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A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of non-coding elements in vivo
The function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with...
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Discovery of tumor-reactive T cell receptors by massively parallel library synthesis and screening
T cell receptor (TCR) gene therapy is a potent form of cellular immunotherapy in which patient T cells are genetically engineered to express TCRs...
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Massively parallel sequencing of human skeletal remains in Vietnam using the precision ID mtDNA control region panel on the Ion S5™ system
Mitochondrial DNA (mtDNA) analysis using Sanger sequencing has been a routine practice for the identification of human skeletal remains. However,...
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Massively parallel sequencing of 25 autosomal STRs including SE33 in four population groups for forensic applications
The introduction of massively parallel sequencing (MPS) in forensic investigation enables sequence-based large-scale multiplexing beyond size-based...
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DNA Sequencing Technologies and DNA Barcoding
DNA barcodes are short, standardized DNA segments that geneticists can use to identify all living taxa. On the other hand, DNA barcoding identifies...
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Population genetic analyses of Eastern Chinese Han nationality using ForenSeq™ DNA Signature Prep Kit
Currently, the most commonly used method for human identification and kinship analysis in forensic genetics is the detection of length polymorphism...
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Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations
Gastric-type cervical adenocarcinoma (GCA) is an aggressive type of endocervical adenocarcinoma characterized by mucinous morphology, gastric-type...
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Next-generation sequencing technology: a boon to agriculture
Next-generation sequencing (NGS) is a massively parallel sequencing technology that has revolutionized genomic research. The goal of genomics is...
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Identification of sequence polymorphisms at 58 STRs and 94 iiSNPs in a Tibetan population using massively parallel sequencing
Massively parallel sequencing (MPS) has rapidly become a promising method for forensic DNA ty**, due to its ability to detect a large number of...
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The forensic landscape and the population genetic analyses of Hainan Li based on massively parallel sequencing DNA profiling
Due to the formation of the Qiongzhou Strait by climate change and marine transition, Hainan island was isolated from the mainland southern China...
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Characterization of 58 STRs and 94 SNPs with the ForenSeq™ DNA signature prep kit in Mexican-Mestizos from the Monterrey city (Northeast, Mexico)
BackgroundSTR allele frequency databases from populations are necessary to take full advantage of the increased power of discrimination offered by...
