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High MICB expression as a biomarker for good prognosis of colorectal cancer
IntroductionMajor histocompatibility complex (MHC) plays an important role in colorectal cancer (CRC) immunity. However, the function of MHC class I...
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Compatibility at amino acid position 98 of MICB reduces the incidence of graft-versus-host disease in conjunction with the CMV status
Graft-versus-host disease (GVHD) and cytomegalovirus (CMV)-related complications are leading causes of mortality after unrelated-donor hematopoietic...
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Proteome-wide analysis reveals potential therapeutic targets for Colorectal cancer: a two-sample mendelian randomization study
BackgroundColorectal cancer (CRC) is a leading cause of cancer-related mortality, highlighting an unmet clinical need for more effective therapies....
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Integrating genomics and proteomics data to identify candidate plasma biomarkers for lung cancer risk among European descendants
BackgroundPlasma proteins are potential biomarkers for complex diseases. We aimed to identify plasma protein biomarkers for lung cancer.
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A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification
Genetic variants can affect gene expression by altering the level of N6-methyladenosine (m 6 A) modifications. A better understanding of the...
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Baicalin acts as an adjuvant to potentiate the activity of azithromycin against Staphylococcus saprophyticus biofilm: an in vitro, in vivo, and molecular study
Staphylococcus saprophyticus is frequently involved in various difficult-to-treat infections due to the formation of biofilms. To identify useful...
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The immunological role of ADAMs in the field of gastroenterological chronic inflammatory diseases and cancers: a review
Metalloproteinases cleave transmembrane proteins that play critical roles in inflammation and cancers. Metalloproteinases include a disintegrin and...
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Intensified NK cell therapy in combination with low-dose chemoradiotherapy against human colorectal cancer
The therapeutic potential of adoptive natural Killer (NK) cells immunotherapy in combination with chemoradiotherapy, the main treatment modality for...
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A vaccine targeting resistant tumours by dual T cell plus NK cell attack
Most cancer vaccines target peptide antigens, necessitating personalization owing to the vast inter-individual diversity in major histocompatibility...
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Antibacterial, antibiofilm, and antivirulence potential of the main diterpenes from Copaifera spp. oleoresins against multidrug‐resistant bacteria
To evaluate the antibacterial, antibiofilm and antivirulence potential of the main diterpenes from Copaifera spp. oleoresins against...
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Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome
BackgroundChronic kidney disease (CKD) is a progressive disease for which there is no effective cure. We aimed to identify potential drug targets for...
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Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition
Multiple Myeloma (MM) is an incurable hematologic malignancy of terminally differentiated plasma cells (PCs), where immune interactions play a key...
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Identifying novel proteins underlying schizophrenia via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data
BackgroundSchizophrenia (SCZ) is a chronic and severe mental illness with no cure so far. Mendelian randomization (MR) is a genetic method widely...
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Immune Evasion of Hepatoma Cancer Stem-Like Cells from Natural Killer Cells
BackgroundPoor prognosis in liver cancer is due to its high frequency of intrahepatic metastasis. Cancer stem-like cells (CSLCs), which possess the...
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RNA modification-related variants in genomic loci associated with body mass index
BackgroundGenome-wide association studies (GWASs) have identified hundreds of loci for body mass index (BMI), but functional variants in these loci...
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Pan-inhibition of the three H2S synthesizing enzymes restrains tumor progression and immunosuppression in breast cancer
BackgroundHydrogen sulfide (H 2 S) is a significant endogenous mediator that has been implicated in the progression of various forms of cancer...
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Establishment of HLA class I and MICA/B null HEK-293T panel expressing single MICA alleles to detect anti-MICA antibodies
Pre- and post-transplantation anti-MICA antibody detection development are associated with an increased rejection risk and low graft survival. We...
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The Therapeutic Application of RBAC in Cancer
Growing evidence suggests that the adaptive cytotoxicCytotoxic cells have prophylactic effects as they work more proficiently in the early phases of...
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NEDD8-activating enzyme inhibition potentiates the anti-myeloma activity of natural killer cells
Natural Killer (NK) cells act as important regulators in the development and progression of hematological malignancies and their suppressor activity...
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Endoglin Regulates Intercellular Interactions between Trophoblast and Natural Killer Cells
AbstractThe interaction of natural killer and trophoblast cells underlies maternal-fetal immune tolerance. The data on the participation of endoglin...
