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Role of liver sinusoidal endothelial cell in metabolic dysfunction-associated fatty liver disease
Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells that represent the interface between blood cells on one side and...
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Semaphorin-3A regulates liver sinusoidal endothelial cell porosity and promotes hepatic steatosis
Prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, increases...
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Oit3, a promising hallmark gene for targeting liver sinusoidal endothelial cells
Liver sinusoidal endothelial cells (LSECs) play a pivotal role in maintaining liver homeostasis and influencing the pathological processes of various...
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Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure
Xanthines such as caffeine and theobromine are among the most consumed psychoactive stimulants in the world, either as natural components of coffee,...
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Antibody screening data of human midgestation liver cells with a focus on hematopoietic, liver sinusoidal endothelial, and hepatoblast cell-populations
ObjectivesCell-surface antigen screening was performed on human fetal liver cells using flow cytometry. The goal was to provide proteomic expression...
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A novel efficient strategy to generate liver sinusoidal endothelial cells from human pluripotent stem cells
Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells (ECs) that play an important role in liver development and...
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Single-cell transcriptome reveals a novel mechanism of C-Kit+-liver sinusoidal endothelial cells in NASH
AimTo understand how liver sinusoidal endothelial cells (LSECs) respond to nonalcoholic steatohepatitis (NASH).
MethodsWe profiled single-LSEC from...
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Highly oxidized albumin is cleared by liver sinusoidal endothelial cells via the receptors stabilin-1 and -2
Oxidized albumin (oxHSA) is elevated in several pathological conditions, such as decompensated cirrhosis, acute on chronic liver failure and liver...
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Liver stiffness measurements predict Sinusoidal Obstructive Syndrome after hematopoietic stem cell transplantation
Sinusoidal Obstructive Syndrome (SOS) is a life-threatening complication after hematopoietic stem-cell transplantation (HSCT), characterized by...
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Sinusoidal Obstruction Syndrome Post Stem Cell Transplant
Hepatic sinusoidal obstruction syndrome (SOS) is a complication related to endothelial damage that appears early after hematopoietic stem cell...
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Liver sinusoidal endothelial cells rely on oxidative phosphorylation but avoid processing long-chain fatty acids in their mitochondria
BackgroundIt is generally accepted that endothelial cells (ECs), primarily rely on glycolysis for ATP production, despite having functional...
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Utility of liver stiffness measurement in the diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic stem cell transplantation
PurposeWe aimed to assess the role of liver stiffness measurement (LSM), evaluated using transient elastography (TE), for the diagnosis of sinusoidal...
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Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation
Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a life-threatening complication after allogeneic hematopoietic cell...
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Single-cell sequencing reveals the existence of fetal vascular endothelial stem cell-like cells in mouse liver
BackgroundA resident vascular endothelial stem cell (VESC) population expressing CD157 and CD200 has been identified recently in the adult mouse....
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Effect of Melatonin on the Expression of LYVE-1 Receptor in Liver Sinusoidal Endothelial Cells of Mice with the Light-Induced Functional Pinealectomy Model
Intragastric administration of melatonin in physiological doses (1 mg/kg body weight) for 14 days to C57BL/6 mice with light-induced functional...
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Co-culture Model for Hepatitis B Virus Infection Using iPSC-Derived Liver Progenitor Cells and Liver Sinusoidal Endothelial Cells
In order to understand the complicated life cycle of hepatitis B virus (HBV), it is necessary to develop a co-culture system for HBV infection using...
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Gut microbiota-derived tryptophan metabolites alleviate liver injury via AhR/Nrf2 activation in pyrrolizidine alkaloids-induced sinusoidal obstruction syndrome
Background and aimsHepatic sinusoidal obstruction syndrome (HSOS) is caused by toxic injury, such as pyrrolizidine alkaloids, to the liver sinusoidal...
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Liver endothelial cells in NAFLD and transition to NASH and HCC
Non-alcoholic fatty liver disease (NAFLD) is considered as the hepatic manifestation of metabolic syndrome, which is characterised by obesity,...
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Fetal liver CD34+ contain human immune and endothelial progenitors and mediate solid tumor rejection in NOG mice
BackgroundTransplantation of CD34 + hematopoietic stem and progenitor cells (HSPC) into immunodeficient mice is an established method to generate...
