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Scabies Itch
Itch is a predominant symptom of scabies, but its public health burden was underappreciated for a long time. The mechanism of scabies itch is not yet...
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Central medial thalamic nucleus dynamically participates in acute itch sensation and chronic itch-induced anxiety-like behavior in male mice
Itch is an annoying sensation consisting of both sensory and emotional components. It is known to involve the parabrachial nucleus (PBN), but the...
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Neural pathways that compel us to scratch an itch
Itch is a unique sensory experience that is responded to by scratching. How pruritogens, which are mechanical and chemical stimuli with the potential...
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Effect of Roflumilast Cream (ARQ-151) on Itch and Itch-Related Sleep Loss in Adults with Chronic Plaque Psoriasis: Patient-Reported Itch Outcomes of a Phase 2b Trial
BackgroundItch is the most bothersome symptom reported by patients with psoriasis. Safe and effective treatments for psoriasis that also address itch...
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ItchyQoL reveals differences in itch symptom experience in routine dermatologic care
Itch is a common symptom of dermatologic diseases associated with significant impairment of health-related quality of life (QoL). This study reveals...
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STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice
BackgroundPatients receiving epidural or intrathecal opioids administration for neuraxial analgesia frequently suffer from an irritating itch. STING...
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Social interactions and olfactory cues are required for contagious itch in mice
The phenomenon of contagious itch, observed in both humans and rodents, remains a topic of ongoing debate concerning its modulators and underlying...
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Hypothalamic orexinergic neurons modulate pain and itch in an opposite way: pain relief and itch exacerbation
Pain and itch are recognized as antagonistic sensations; pain suppresses itch and inhibition of pain generates itch. There is still a lack of...
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Peripheral signaling pathways contributing to non-histaminergic itch in humans
BackgroundChronic itch (chronic pruritus) is a major therapeutic challenge that remains poorly understood despite the extensive recent analysis of...
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Novel Topical Treatments for Itch
The experience of itch often poses a burden on patient quality of life and has the capacity to inflict significant suffering. Topical therapies are a...
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Orexin neurons play contrasting roles in itch and pain neural processing via projecting to the periaqueductal gray
Pain and itch are recognized as antagonistically regulated sensations; pain suppresses itch, whilst pain inhibition enhances itch. The neural...
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Pathogenic mechanisms underlying itch in atopic dermatitis: the emerging role of neuroimmune interactions
Itch is a frequent dermatological sensation that can occur in a variety of skin conditions, including atopic dermatitis, inflammatory disorders...
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Itch in recessive dystrophic epidermolysis bullosa: findings of PEBLES, a prospective register study
BackgroundItch is common and distressing in epidermolysis bullosa (EB) but has not previously been studied in depth in different recessive dystrophic...
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The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis
The activation of apoptosis signalling by TRAIL (TNF-related apoptosis-inducing ligand) through receptor binding is a fundamental mechanism of cell...
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Neuroimmune Interactions in Acute and Chronic Itch
Itch is a sensory experience of the skin that is familiar to all humans. Recent studies have established that the immune system and central and...
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CircRNA ITCH Inhibits Epithelial–Mesenchymal Transformation and Promotes Apoptosis in Papillary Thyroid Carcinoma via miR-106a-5p/JAZF1 Axis
Circular RNA ITCH (circ-ITCH) is implicated in papillary thyroid carcinoma (PTC) development. Nevertheless, the more detailed molecular mechanism...
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The COL6A5-p.Glu2272* mutation induces chronic itch in mice
Pruritus is a common irritating sensation that provokes the desire to scratch. Environmental and genetic factors contribute to the onset of pruritus....
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Ligand recognition and G protein coupling of the human itch receptor MRGPRX1
MRGPRX1, a Mas-related GPCR (MRGPR), is a key receptor for itch perception and targeting MRGPRX1 may have potential to treat both chronic itch and...
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Economic Burden of Itch-Related Sleep Loss in Moderate-to-Severe Atopic Dermatitis in the United Kingdom
IntroductionAtopic dermatitis is associated with intense itch, which has been shown to cause sleep disruption that significantly impacts the lives of...
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The Many Challenges of Human Experimental Itch Research
Itch has long been a neglected sense within somatosensory research, and with good reason: acute itch, although relatively easy to trigger, is...