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Evaluating inter-individual variability captured by the Eleveld pharmacokinetics model
Inter-individual variability in Pharmacokinetic (PK) and Pharmacodynamic (PD) models significantly affects the accuracy of Target Controlled Infusion...
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Inter-individual, hemispheric and sex variability of brain activations during numerosity processing
Numerosity perception is a fundamental and innate cognitive function shared by both humans and many animal species. Previous research has primarily...
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Intra- and inter-individual cognitive variability in schizophrenia and bipolar spectrum disorder: an investigation across multiple cognitive domains
There is substantial cognitive heterogeneity among patients with schizophrenia (SZ) and bipolar disorders (BD). More knowledge about the magnitude...
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Modelling inter-individual variability in acute and adaptive responses to interval training: insights into exercise intensity normalisation
PurposeTo investigate the influence of exercise intensity normalisation on intra- and inter-individual acute and adaptive responses to an interval...
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Inter-individual variability in mechanical pain sensation in patients with cervicogenic headache: an explorative study
Currently, evidence for effective physiotherapy interventions in patients with cervicogenic headache (CeH) is inconsistent. Although inter-individual...
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Glycan clock of ageing—analytical precision and time-dependent inter- and i-individual variability
Ageing is a complex biological process with variations among individuals, leading to the development of ageing clocks to estimate biological age....
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Factors affecting inter-individual variability in endoxifen concentrations in patients with breast cancer: results from the prospective TOTAM trial
IntroductionEndoxifen—the principal metabolite of tamoxifen—is subject to a high inter-individual variability in serum concentration. Numerous...
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Brain criticality predicts individual levels of inter-areal synchronization in human electrophysiological data
Neuronal oscillations and their synchronization between brain areas are fundamental for healthy brain function. Yet, synchronization levels exhibit...
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Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability
Variability in disease severity caused by a microbial pathogen is impacted by each infection representing a unique combination of host and pathogen...
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Accuracy and precision of responses to visual analog scales: Inter- and intra-individual variability
Visual analog scales (VASs) are gaining popularity for collecting responses in computer administration of psychometric tests and surveys. The VAS...
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Dynamic gap analysis of valgus knees shows large inter-individual variability of gaps
PurposeThe purpose of this study was to investigate the dynamic gap widths of valgus knees in extension and flexion to evaluate the influence of...
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How Can iEEG Be Used to Study Inter-Individual and Developmental Differences?
Inter-individual differences, including but not limited to those that distinguish children from adolescents and younger from older adults, are a...
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Inter-specific and inter-individual trait variability matter in surface sediment reworking rates of intertidal benthic foraminifera
Although benthic foraminifera are an important component of meiofauna and contribute to carbonate production and carbon/nitrogen cycles, their role...
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Inter-individual variability in disease expression: the Tudor-Churchill spectrum
Henry VIII and Winston Churchill are clinically instructive when appreciating inter-individual variability in disease expression. Both were...
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Small networks of expressed genes in the whole blood and relationships to profiles in circulating metabolites provide insights in inter-individual variability of feed efficiency in growing pigs
BackgroundFeed efficiency is a research priority to support a sustainable meat production. It is recognized as a complex trait that integrates...
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The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity
Fear-related pathologies are among the most prevalent psychiatric conditions, having inappropriate learned fear and resistance to extinction as...
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Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS
Transcranial direct current stimulation (tDCS) has the potential to modulate cognitive training in healthy aging; however, results from various...
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In vitro–in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans
New approach methodologies predicting human cardiotoxicity are of interest to support or even replace in vivo-based drug safety testing. The present...
