Search
Search Results
-
IL-17A Aggravated Blood–Brain Barrier Disruption via Activating Src Signaling in Epilepsy Mice
Inflammation is an important pathogenic driving force in the genesis and development of epilepsy. The latest researches demonstrated that IL-17A...
-
Identification and functional characterization of fish IL-17 receptors suggest important roles in the response to nodavirus infection
Th17 is a lymphocyte T helper (Th) subpopulation relevant in the control and regulation of the immune response characterized by the production of...
-
Cigarette and IL-17A synergistically induce bronchial epithelial-mesenchymal transition via activating IL-17R/NF-κB signaling
BackgroundIL-17A directly induces epithelial-mesenchymal transition (EMT) in alveolar epithelial cells. It could coordinate with cigarette smoke...
-
CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology
Interleukin-17A (IL-17A) is a key mediator of protective immunity to yeast and bacterial infections but also drives the pathogenesis of several...
-
FXYD3 enhances IL-17A signaling to promote psoriasis by competitively binding TRAF3 in keratinocytes
Psoriasis is a common chronic inflammatory skin disease characterized by inflammatory cell infiltration and epidermal hyperplasia. However, the...
-
An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses
Helicobacter pylori causes chronic gastric infection that can lead to peptic ulcers and is an identified risk factor for gastric cancer development....
-
-
Sex Dimorphism in Pain Threshold and Neuroinflammatory Response: The Protective Effect of Female Sexual Hormones on Behavior and Seizures in an Allergic Rhinitis Model
Our previous research demonstrated that allergic rhinitis could impact behavior and seizure threshold in male mice. However, due to the complex...
-
Genetic association between interleukin-17 and susceptibility to rheumatoid arthritis
BackgroundThe pathogenesis of rheumatoid arthritis (RA) is an immune imbalance, in which various inflammatory immune cells and pro-inflammatory...
-
IκBζ controls IL-17-triggered gene expression program in intestinal epithelial cells that restricts colonization of SFB and prevents Th17-associated pathologies
Control of gut microbes is crucial for not only local defense in the intestine but also proper systemic immune responses. Although intestinal...
-
Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice
BackgroundHelicobacter pylori (H. Pylori), is an established causative factor for the development of gastric cancer and the induction of persistent...
-
C-EBPβ mediates in cigarette/IL-17A-induced bronchial epithelial–mesenchymal transition in COPD mice
BackgroundCigarettes smoking and IL-17A contribute to chronic obstructive pulmonary disease (COPD), and have synergistical effect on bronchial...
-
Immune-related adverse events (irAEs) in ankylosing spondylitis (AS) patients treated with interleukin (IL)-17 inhibitors: a systematic review and meta-analysis
BackgroundAnkylosing spondylitis (AS) is a chronic inflammatory rheumatic disease characterized by immune system dysregulation and inflammation in...
-
MicroRNA-146a limits tumorigenic inflammation in colorectal cancer
Chronic inflammation can drive tumor development. Here, we have identified microRNA-146a (miR-146a) as a major negative regulator of colonic...
-
Galectin-1 Inhibited LPS-Induced Autophagy and Apoptosis of Human Periodontal Ligament Stem Cells
Periodontitis is a widespread human chronic inflammatory disease of the tooth-surrounding tissues, which induces the destruction of periodontium and...
-
Associations of IL-17 and IL-17 receptor polymorphisms with Behçet’s disease in Denizli Province of Turkey
Although the etiopathogenesis of Behçet’s disease is not known, studies conducted in different populations show that it is a multifactorial disease...
-
IL-17 Signaling in the Tumor Microenvironment
Inflammation is recognized as representing a double-edged sword in terms of tumor growth, in some instances contributing to attenuation of growth and...
-
Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L.
BackgroundCognitive health is of great interest to society, with neuroinflammation and systemic inflammation age-related risk factors that are linked...
-
The IL-17 family in diseases: from bench to bedside
The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and recently, all of its related receptors have been discovered. IL-17 was...
