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The RHCE gene encodes the chicken blood system I
BackgroundThere are 13 known chicken blood systems, which were originally detected by agglutination of red blood cells by specific alloantisera. The...
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Thymidine phosphorylase facilitates retinoic acid inducible gene-I induced endothelial dysfunction
Activation of nucleic acid sensors in endothelial cells (ECs) has been shown to drive inflammation across pathologies including cancer,...
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ACE I/D gene polymorphisms and polycystic ovary syndrome manifestations
ObjectivePolycystic ovary syndrome (PCOS) is a common multifactorial endocrine disorder affecting women of reproductive age. ACE enzyme is involved...
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CCAAT Promoter element regulates transgenerational expression of the MHC class I gene
Transgenerational gene expression depends on both underlying DNA sequences and epigenetic modifications. The latter, which can result in transmission...
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Map** brain networks in MPS I mice and their restoration following gene therapy
Mucopolysaccharidosis type I (MPS I) is an inherited lysosomal disorder that causes syndromes characterized by physiological dysfunction in many...
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Prenatal diagnosis of non-typical Chiari malformation type I associated with de novo Nuclear Factor I A gene mutation: a case report
BackgroundChiari malformation is one of the most common Central nervous system (CNS) abnormalities that can be detected in routine fetal scanning....
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Comparative Study of Two Himalayan Snow Trouts, Schizothorax esocinus and Schizothorax curvifrons Within the Schizothoracinae and Other Nearest Relatives of Cyprinidae, Inferred from Mitochondrial Sequences of Cytochrome b (Cyt-b) and Cytochrome Oxidase I (Co-I) Gene
The Himalayan region encompasses varied aquatic ecosystems, characterized by the presence of diverse ichthyofauna, particularly represented by...
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Upregulation of MHC I Antigen Processing Machinery Gene Expression in Breast Cancer Cells by Trichostatin A
AbstractEpigenetic alterations associated with cancer have been shown to facilitate tumorigenesis and promote metastasis. In the study of cancer...
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Modeling Glutaric Aciduria Type I in human neuroblastoma cells recapitulates neuronal damage that can be rescued by gene replacement
Glutaric Aciduria type I (GA1) is a rare neurometabolic disorder caused by mutations in the GDCH gene encoding for glutaryl-CoA dehydrogenase (GCDH)...
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ACE Gene I/D Polymorphism and Cardiometabolic Risk Factors: A Cross Sectional Study of Rural Population
The D allele has been identified as being linked to cardiovascular disease since the discovery of an insertion/deletion (I/D) polymorphism in the ACE...
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Gene Therapy Trials
This chapter contains a listing and summary of gene therapy studies for Age-Related Macular Degeneration Treatment. Countries with gene therapy...
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The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes
The chicken major histocompatibility complex (MHC, also known as the BF-BL region of the B locus) is notably small and simple with few genes, most of...
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Plant Gene Regulatory Networks Methods and Protocols
This second edition details protocols that analyze and explore gene regulatory networks (GRNs). Chapters guide readers through experimental...
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Gene Transfer
In addition to vertical gene transfer between generations, microbes often transfer their genes horizontally. Horizontal gene transfer contributes...
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Nanodelivery in Gene Therapy
Gene therapy stands as a revolutionary approach in medicine, aiming to rectify genetic abnormalities by introducing therapeutic genes or regulating...
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Suicide gene therapy using allogeneic adipose tissue-derived mesenchymal stem cell gene delivery vehicles in recurrent glioblastoma multiforme: a first-in-human, dose-escalation, phase I clinical trial
BackgroundGlioblastoma multiforme (GBM) is associated with remarkably poor prognosis, and its treatment is challenging. This investigation aimed to...
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Gene Drives
A “gene drive” is a version of gene editing—a newer, more precise way to change a DNA (or RNA) sequence; in this case, combining a guide RNA with an...
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Potential role of serum copeptin among smoker T2DM patients with emphasis to ACE I/D gene polymorphism predicting DN
Diabetic nephropathy represents one of the main long-term complications in T2DM patients. Cigarette smoking represents one of modifiable renal risk...
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Calcium electroporation of esophageal cancer induces gene expression changes: a sub-study of a phase I clinical trial
PurposeIn this study, we aim to investigate gene expression changes in tumor samples obtained from patients with esophageal cancer treated with...
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Identification of a candidate gene for the I locus determining the dominant white bulb color in onion (Allium cepa L.)
Key messageThrough a map-based cloning approach, a gene coding for an R2R3-MYB transcription factor was identified as a causal gene for the
I locus...