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Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens
Accumulating evidence indicates that HOXA9 dysregulation is necessary and sufficient for leukemic transformation and maintenance. However, it remains...
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HOXA9 transcription factor is a double-edged sword: from development to cancer progression
The HOXA9 transcription factor serves as a molecular orchestrator in cancer stemness, epithelial-mesenchymal transition (EMT), metastasis, and...
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HOXA9 versus HOXB9; particular focus on their controversial role in tumor pathogenesis
The Homeobox (HOX) gene family is essential to regulating cellular processes because it maintains the exact coordination required for tissue...
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Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesis
Homeodomain transcription factor A9 (HOXA9) is a member of the HOX cluster family of transcription factors that are crucially involved in embryo...
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Desflurane alleviates LPS-induced acute lung injury by modulating let-7b-5p/HOXA9 axis
Acute lung injury (ALI) is characterized by acute respiratory failure with tachypnea and widespread alveolar infiltrates, badly affecting patients’...
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Exploring the expression and clinical significance of the miR-140-3p-HOXA9 axis in colorectal cancer
PurposeThis study aims to investigate the expression patterns and clinical significance of miR-140-3p and homeobox A9 (HOXA9) in colorectal cancer...
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RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9
BackgroundThe oncogenic protein HOXA9 plays a critical role in leukemia transformation and maintenance, and its aberrant expression is a hallmark of...
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Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential
HOXA9 functioning as a transcription factor is one of the members of HOX gene family, which governs multiple cellular activities by facilitating...
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Propofol inhibits glioma progression by regulating circMAPK4/miR-622/HOXA9 axis
Propofol has a tumor-suppressive role in glioma, but the mechanism by which propofol is involved in glioma progression is largely unknown. This study...
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LncRNA MAFG-AS1-induced acute myeloid leukemia development via modulating miR-147b/HOXA9
Recent references discovered that lncRNAs acted roles in malignant cancer development. However, the role of MAFG-AS1 in acute myeloid leukemia (AML)...
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HOXA9 has the hallmarks of a biological switch with implications in blood cancers
Blood malignancies arise from the dysregulation of haematopoiesis. The type of blood cell and the specific order of oncogenic events initiating...
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Circ_0026359 induces HOXA9 to regulate gastric cancer malignant progression through miR-140-3p
Recent researches indicate the key role of circRNA in gastric cancer (GC) progression. However, the role of circ_0026359 in GC progression remains...
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Evaluation of the HOXA9 and MEIS1 genes as a potential biomarker in adult acute myeloid leukemia
BackgroundAcute myeloid leukemia (AML) is a heterogeneous disorder encompassing a set of hematopoietic tumors that develop when the myeloid precursor...
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NK cell activity and methylated HOXA9 ctDNA as prognostic biomarkers in patients with non-small cell lung cancer treated with PD-1/PD-L1 inhibitors
BackgroundPD-1/PD-L1 inhibitors have improved survival for patients with non-small cell lung cancer (NSCLC). We evaluated natural killer cell...
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17β-neriifolin from unripe fruits of Cerbera manghas suppressed cell proliferation via the inhibition of HOXA9-dependent transcription and the induction of apoptosis in the human AML cell line THP-1
Homeobox A9 (HOXA9) is a transcription factor that is overexpressed in acute myeloid leukemia (AML). It is associated with the pathogenesis and...
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HOXA9 gene inhibits proliferation and differentiation and promotes apoptosis of bovine preadipocytes
BackgroundHox gene family is an important transcription factor that regulates cell process, and plays a role in the process of adipocytes...
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HOXA9 gene promotor methylation and copy number variation of SOX2 and HV2 genes in cell free DNA: A potential diagnostic panel for non-small cell lung cancer
BackgroundMost cases of lung cancer are diagnosed at advanced stage. Detection of genetic and epigenetic markers in cell-free DNA (cfDNA) is a...
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A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML
Relapse is a major challenge to therapeutic success in acute myeloid leukemia (AML) and can be partly associated with heterogeneous leukemic stem...
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MicroRNA-638 inhibits the progression of breast cancer through targeting HOXA9 and suppressing Wnt/β-cadherin pathway
BackgroundPrevious studies had shown that microRNA-638 (miR-638) exhibited different effects in malignant tumors. Moreover, the function of miR-638...
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Overexpression of HOXA9 upregulates NF-κB signaling to promote human hematopoiesis and alter the hematopoietic differentiation potentials
BackgroundThe HOX genes are master regulators of embryogenesis that are also involved in hematopoiesis. HOXA9 belongs to a cluster of HOX genes that...
