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G1 Phase: Components, Conundrums, Context
A eukaryotic cell must coordinate DNA synthesis and chromosomal segregation to generate a faithful replica of itself. These events are confined to...
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A transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress
The family of hypoxia-inducible transcription factors (HIF) is activated to adapt cells to low oxygen conditions, but is also known to regulate some...
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A fast-acting lipid checkpoint in G1 prevents mitotic defects
Lipid synthesis increases during the cell cycle to ensure sufficient membrane mass, but how insufficient synthesis restricts cell-cycle entry is not...
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Targeting the DYRK1A kinase prevents cancer progression and metastasis and promotes cancer cells response to G1/S targeting chemotherapy drugs
Metastatic cancer remains incurable as patients eventually loose sensitivity to targeted therapies and chemotherapies, further leading to poor...
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Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions
DNA replicates once per cell cycle. Interfering with the regulation of DNA replication initiation generates genome instability through...
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Clotrimazole inhibits growth of multiple myeloma cells in vitro via G0/G1 arrest and mitochondrial apoptosis
Patients with multiple myeloma (MM) experience relapse and drug resistance; therefore, novel treatments are essential. Clotrimazole (CTZ) is a...
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Advancing industrial wastewater treatment through comprehensive evaluation and innovative technology: a G1-entropy improved TOPSIS model approach
This study proposes a comprehensive evaluation system for industrial sewage treatment projects based on the G1-Entropy Improved TOPSIS model to...
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G1/S restriction point coordinates phasic gene expression and cell differentiation
Pluripotent embryonic stem cells have a unique cell cycle structure with a suppressed G1/S restriction point and little differential expression...
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APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition
BackgroundIn addition to functioning as a precise monitoring mechanism in cell cycle, the anaphase-promoting complex/cyclosome (APC/C) is reported to...
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Cystic echinococcosis in cattle and sheep caused by Echinococcus granulosus sensu stricto genotypes G1 and G3 in the USA
BackgroundEndemic domestic dog-ruminant cycles and human cystic echinococcosis caused by Echinococcus granulosus have been sporadically reported in...
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Association of methylation status of ABCA1/G1 genes with the risk of coronary artery disease
BackgroundATP-binding cassette transporters A1/G1 (ABCA1/G1) is a main regulator of HDL (high-density lipoprotein) formation and reverse cholesterol...
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Lansoprazole inhibits the development of sessile serrated lesions by inducing G1 arrest via Skp2/p27 signaling pathway
BackgroundAlthough the serrated-neoplasia pathway reportedly accounts for 15–30% of colorectal cancer (CRC), no studies on chemoprevention of sessile...
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Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors
Phosphatidylinositol 3-kinase alpha (PI3Kα) inhibitors are currently evaluated for the therapy of esophageal squamous cell carcinoma (ESCC). It is of...
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CDC7-independent G1/S transition revealed by targeted protein degradation
The entry of mammalian cells into the DNA synthesis phase (S phase) represents a key event in cell division
1 . According to current models of the cell...
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Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors
PurposeWe aimed to construct novel nomograms for nodal and distant metastasis for patients with G1 and G2 colorectal neuroendocrine tumors (NETs).
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A comprehensive risk assessment method for hot work in underground mines based on G1-EWM and unascertained measure theory
A risk assessment method for hot work based on G1-EWM and unascertained measurement theory was proposed to prevent hot work accidents in underground...
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MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progression
MC1R, a G-protein coupled receptor, triggers ultraviolet light-induced melanin synthesis and DNA repair in melanocytes and is implicated in the...
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The G1/S repressor WHI5 is expressed at similar levels throughout the cell cycle
ObjectivesWhile it is clear that cells need to grow before committing to division at the G1/S transition of the cell cycle, how cells sense their...
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A benzimidazolium salt induces apoptosis and arrests cells at sub-G1 phase in epithelial ovarian cancer cells
BackgroundOvarian cancer, also known as a silent killer, is the deadliest gynecological cancer in women worldwide. Epithelial ovarian cancers...
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Komagataeibacter saccharivorans strain BC-G1: an alternative strain for production of bacterial cellulose
The current study represents the isolation and characterization of cellulose producing bacteria from rotten grape fruit. The best Bacterial Cellulose...
