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JAZF1 safeguards human endometrial stromal cells survival and decidualization by repressing the transcription of G0S2
Decidualization of human endometrial stromal cells (hESCs) is essential for the maintenance of pregnancy, which depends on the fine-tuned regulation...
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G0S2 regulates innate immunity in Kawasaki disease via lncRNA HSD11B1-AS1
BackgroundKawasaki disease (KD) is a systemic vasculitis that is currently the most common cause of acquired heart disease in children. However, its...
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Robust machine−learning based prognostic index using cytotoxic T lymphocyte evasion genes highlights potential therapeutic targets in colorectal cancer
BackgroundA minute fraction of patients stands to derive substantial benefits from immunotherapy, primarily attributable to immune evasion. Our...
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Integrative analyses and validation of ferroptosis-related genes and mechanisms associated with cerebrovascular and cardiovascular ischemic diseases
BackgroundThere has been a gradual increase in the occurrence of cardiovascular and cerebrovascular ischemic diseases, particularly as comorbidities....
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Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages
Recent studies reported that Methyl-CpG–binding domain protein 2 (MBD2) promoted M2 macrophages accumulation to increase bleomycin-induced pulmonary...
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Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis
ATGL is a key enzyme in intracellular lipolysis and plays an important role in metabolic and cardiovascular diseases. ATGL is tightly regulated by a...
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The Predictive Value of Neutrophil Extracellular Trap-Related Risk Score in Prognosis and Immune Microenvironment of Colorectal Cancer Patients
Colorectal cancer (CRC) has brought great healthy burden for patients. Neutrophil extracellular traps (NETs) have been explored in several tumors,...
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Analysis of Prospective Genetic Indicators for Prenatal Exposure to Arsenic in Newborn Cord Blood of Using Machine Learning
Using a machine learning methods, we aim to find biological effect biomarkers of prenatal arsenic exposure in newborn cord blood. From the Gene...
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Comprehensive transcriptomic analysis unveils macrophage-associated genes for establishing an abdominal aortic aneurysm diagnostic model and molecular therapeutic framework
BackgroundAbdominal aortic aneurysm (AAA) is a highly lethal cardiovascular disease. The aim of this research is to identify new biomarkers and...
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Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
BackgroundIonizing radiation (IR) therapy is the standard first-line treatment for newly diagnosed patients with glioblastoma (GBM), the most common...
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Targeting copper death genoty** associated gene RARRES2 suppresses glioblastoma progression and macrophages infiltration
BackgroundCopper homeostasis is associated with malignant biological behavior in various tumors. The excessive accumulation of copper can induce...
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Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
BackgroundIntramuscular fat (IMF) content and its fatty acid (FA) composition are typically controlled by several genes, each with a small effect. In...
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Integrated analysis of mRNA and long noncoding RNA profiles in peripheral blood mononuclear cells of patients with bronchial asthma
BackgroundBronchial asthma is a heterogeneous disease with distinct disease phenotypes and underlying pathophysiological mechanisms. Long non-coding...
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Single-cell transcriptomics by clinical course of Mycobacterium avium complex pulmonary disease
Mycobacterium avium complex pulmonary disease (MAC-PD) has a heterogeneous clinical course. However, immune profiles associated with MAC-PD clinical...
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RNA-Seq transcriptome analysis reveals Maackia amurensis leukoagglutinin has antitumor activity in human anaplastic thyroid cancer cells
BackgroundLectins are carbohydrate-binding molecules that can bind specifically to the sugar residues of glycoconjugates and are found in almost all...
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Transcriptional analysis of the expression and prognostic value of lipid droplet-localized proteins in hepatocellular carcinoma
The accumulation of lipid droplets (LDs) in hepatocytes is the main pathogenesis in nonalcoholic fatty liver disease (NAFLD), which is also the key...
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LncRNAs in Kawasaki disease and Henoch-Schönlein purpura: mechanisms and clinical applications
Kawasaki disease (KD) and Henoch-Schönlein purpura (HSP) are the two most predominant types of childhood vasculitis. In childhood vasculitis, factors...
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Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis
BackgroundPancreatic cancer is the fourth leading cause of cancer deaths in the United States both in females and in males, and is projected to...
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Integration of single-cell and bulk RNA sequencing to establish a prognostic signature based on tumor-associated macrophages in colorectal cancer
Several studies have shown significant involvement of tumor-associated macrophages (TAMs) in the tumor microenvironment and cancer progression....
