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Use of Bioinformatics in High-Throughput Drug Screening
Bioinformatics has emerged as a vital component of almost all the fields of biological sciences. Its ability to quickly generate, analyze, and...
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Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine
In recent years, the rapid emergence of 3D organoid technology has garnered significant attention from researchers. These miniature models accurately...
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AI-Driven Enhancements in Drug Screening and Optimization
The greatest challenge in drug discovery remains the high rate of attrition across the different phases of the process, which cost the industry...
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Nanofluidic Technologies for Drug Screening and Drug Delivery
Recently, nanofluidics exploiting 10–1000 nm spaces has developed and suggested a potential of novel analytical methods for pharmaceutical studies...
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Virtual Screening Process: A Guide in Modern Drug Designing
Due to its capacity to drastically cut the cost and time necessary for experimental screening of compounds, virtual screening (VS) has grown to be a...
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Drug screening on digital microfluidics for cancer precision medicine
Drug screening based on in-vitro primary tumor cell culture has demonstrated potential in personalized cancer diagnosis. However, the limited number...
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Review: Human stem cell-based 3D in vitro angiogenesis models for preclinical drug screening applications
Vascular diseases are the underlying pathology in many life-threatening illnesses. Human cellular and molecular mechanisms involved in angiogenesis...
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Droplet microarray platforms for high-throughput drug screening
AbstractHigh-throughput screening platforms are fundamental for the rapid and efficient processing of large amounts of experimental data....
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Applications of Molecular Dynamics Simulations in Drug Discovery
In the current drug development process, molecular dynamics (MD) simulations have proven to be very useful. This chapter provides an overview of the...
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Construction of multiple concentration gradients for single-cell level drug screening
Isolation and manipulation of single cells play a crucial role in drug screening. However, previously reported single-cell drug screening lacked...
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Benchmarking compound activity prediction for real-world drug discovery applications
Identifying active compounds for target proteins is fundamental in early drug discovery. Recently, data-driven computational methods have...
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Biostatistical Investigation Using Docking Mechanism and Its Database to Investigate Drug Design, Drug Discovery, Drug Metabolism and Prediction Via Drug–Drug Interactions
Molecular docking is an important tool for structure-based drug design and is being widely used to study molecular interactions with proteins at...
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Consensus holistic virtual screening for drug discovery: a novel machine learning model approach
In drug discovery, virtual screening is crucial for identifying potential hit compounds. This study aims to present a novel pipeline that employs...
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Repurposing existing drugs for monkeypox: applications of virtual screening methods
BackgroundMonkeypox is endemic to African region and has become of Global concern recently due to its outbreaks in non-endemic countries. Although,...
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Applications of Evolutionary Computation in Drug Design
Evolutionary algorithms have been widely adopted for solving many of the complex tasks involved in drug design. Here, applications to two different...
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Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes
Selective chemical inhibitors are critical for reaction phenoty** to identify drug-metabolizing enzymes that are involved in the elimination of...
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Development of an Extracellular Matrix Plate for Drug Screening Using Patient-Derived Tumor Organoids
With the advances in organoid culture, patient-derived organoids are utilized in diverse fields to broaden our understanding of conventional...
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Insights into Translational and Biomedical Applications of Hydrogels as Versatile Drug Delivery Systems
Hydrogels are a network of crosslinked polymers which can hold a huge amount of water in their matrix. These might be soft, flexible, and porous...
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Machine Learning Approaches to 3D Models for Drug Screening
The creation of precise, functional 3D tissues can enable effective drug screening as well as advancements in regenerative medicine. However, the...
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A clinically compatible in vitro drug-screening platform identifies therapeutic vulnerabilities in primary cultures of brain metastases
PurposeBrain metastases represent the most common intracranial tumors in adults and are associated with a poor prognosis. We used a personalized in...
