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GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break repair and determining cancer radiosensitivity
BackgroundDNA double-strand break (DSB) induction and repair are important events for determining cell survival and the outcome of cancer...
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DNA double-strand break–capturing nuclear envelope tubules drive DNA repair
Current models suggest that DNA double-strand breaks (DSBs) can move to the nuclear periphery for repair. It is unclear to what extent human DSBs...
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Di- and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair
Histone H3 Lys36 (H3K36) methylation and its associated modifiers are crucial for DNA double-strand break (DSB) repair, but the mechanism governing...
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Widespread chromatin context-dependencies of DNA double-strand break repair proteins
DNA double-strand breaks are repaired by multiple pathways, including non-homologous end-joining (NHEJ) and microhomology-mediated end-joining...
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Fatty acid oxidation facilitates DNA double-strand break repair by promoting PARP1 acetylation
DNA repair is a tightly coordinated stress response to DNA damage, which is critical for preserving genome integrity. Accruing evidence suggests that...
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DNA double-strand break end synapsis by DNA loop extrusion
DNA double-strand breaks (DSBs) occur every cell cycle and must be efficiently repaired. Non-homologous end joining (NHEJ) is the dominant pathway...
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The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair
Glucose metabolism and DNA repair are fundamental cellular processes frequently dysregulated in cancer. In this study, we define a direct role for...
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TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) stands as the fifth most prevalent malignant tumor on a global scale and presents as the second leading cause of...
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DNA double-strand break genetic variants in patients with premature ovarian insufficiency
Premature ovarian insufficiency (POI) is a clinically heterogeneous disease that may seriously affect the physical and mental health of women of...
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Germline specific genes increase DNA double-strand break repair and radioresistance in lung adenocarcinoma cells
In principle, germline cells possess the capability to transmit a nearly unaltered set of genetic material to infinite future generations, whereas...
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SRSF4 Confers Temozolomide Resistance of Glioma via Accelerating Double Strand Break Repair
Temozolomide (TMZ)-based chemotherapy plays a central part in glioma treatment. However, prominent resistance to TMZ is a major change by now. In...
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DNA double-strand break-free CRISPR interference delays Huntington’s disease progression in mice
Huntington’s disease (HD) is caused by a CAG repeat expansion in the huntingtin ( HTT ) gene. CRISPR-Cas9 nuclease causes double-strand breaks (DSBs)...
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Boric Acid Affects the Expression of DNA Double-Strand Break Repair Factors in A549 Cells and A549 Cancer Stem Cells: An In Vitro Study
DNA double-strand break (DSB) repair genes interact with tumor stemness- and resistance-associated processes in cancer stem cells (CSCs). Therefore,...
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Supercoiled DNA Minicircles under Double-strand Breaks
Understanding how supercoiled DNA releases intramolecular stress is essential for its functional realization. However, the molecular mechanism...
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Mre11-Rad50 oligomerization promotes DNA double-strand break repair
The conserved Mre11-Rad50 complex is crucial for the detection, signaling, end tethering and processing of DNA double-strand breaks. While it is...
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Developmental progression of DNA double-strand break repair deciphered by a single-allele resolution mutation classifier
DNA double-strand breaks (DSBs) are repaired by a hierarchically regulated network of pathways. Factors influencing the choice of particular repair...
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BMAL1 collaborates with CLOCK to directly promote DNA double-strand break repair and tumor chemoresistance
Accumulating evidence indicates a correlation between circadian dysfunction and genomic instability. However, whether the circadian machinery...
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Linear interaction between replication and transcription shapes DNA break dynamics at recurrent DNA break Clusters
Recurrent DNA break clusters (RDCs) are replication-transcription collision hotspots; many are unique to neural progenitor cells. Through...
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The type IIS restriction enzyme MmeI can cut across a double-strand break
BackgroundType-IIS restriction enzymes cut outside their recognition sites, allowing them to remove their binding sites upon digestion. This feature...
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HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization
HJURP is overexpressed in several cancer types and strongly correlates with patient survival. However, the mechanistic basis underlying the...
