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Biosynthesis of β-Amino Acid-Containing Macrolactam Polyketides
β-Amino acid-containing macrolactam antibiotics are an important class of macrocyclic polyketides in Actinobacteria. These macrolactam antibiotics...
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VCD of Biological Substances: Effects of d-Amino Acid Residues on Supramolecular Chirality
This chapter describes the VCD of biological substances. Targets are amino acids, oligopeptides, proteins and protein aggregates. Solid-state VCD...
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Prediction of Functional Effects of Protein Amino Acid Mutations
Human Single Amino Acid Polymorphisms (SAPs) or Single Amino Acid Variants (SAVs) usually named as nonsynonymous Single Nucleotide Variants nsSNVs)...
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Amino Acid Transport Defects
Disorders associated with the malfunction of amino acid transporters mainly affect the function of the intestine, kidney, brain, and liver. Mutations...
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Structural and functional analysis of hyper-thermostable ancestral L-amino acid oxidase that can convert Trp derivatives to D-forms by chemoenzymatic reaction
Production of D-amino acids (D-AAs) on a large-scale enables to provide precursors of peptide therapeutics. In this study, we designed a novel...
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Amino acid metabolism in health and disease
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth,...
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Clustered surface amino acid residues modulate the acid stability of GH10 xylanase in fungi
AbstractAcidic xylanases are widely used in industries such as biofuels, animal feeding, and fruit juice clarification due to their tolerance to...
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Amino Acids
Since discovery of Corynebacterium glutamicum in 1956, amino acid production by microbial fermentation is one of most successful biotechnology models...
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Amino acid intake strategies define pluripotent cell states
Mammalian preimplantation development is associated with marked metabolic robustness, and embryos can develop under a wide variety of nutrient...
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Biosynthesis of macrolactam antibiotics with β-amino acid polyketide starter units
Macrolactam antibiotics incorporating β-amino acid polyketide starter units, isolated primarily from Actinomycetes species, show significant...
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Amino Acids
Amino acids are organic compounds containing an amino group (–NH2) and a carboxyl group (–COOH) along with a side chain (–R) specific to each amino...
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Amino Acid PET/MRI in Neuro-oncology
FDG-PET is the most common modality for metabolic imaging in brain tumors that can provide prognostic information at initial assessment of patients...
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Innovative approaches for amino acid production via consolidated bioprocessing of agricultural biomass
Agricultural plantations in Indonesia and Malaysia yield substantial waste, necessitating proper disposal to address environmental concerns. Yet,...
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Blocking of amino acid transporter OsAAP7 promoted tillering and yield by determining basic and neutral amino acids accumulation in rice
BackgroundAmino acids are not only the main form of N in rice, but also are vital for its growth and development. These processes are facilitated by...
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Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter
Recent cryoEM studies elucidated details of the structural basis for the substrate selectivity and translocation of heteromeric amino acid...
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Systemic perturbations in amino acids/amino acid derivatives and tryptophan pathway metabolites associated with murine influenza A virus infection
BackgroundInfluenza A virus (IAV) is the only influenza virus causing flu pandemics (i.e., global epidemics of flu disease). Influenza (the flu) is a...
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Genetic architecture of tuber-bound free amino acids in potato and effect of growing environment on the amino acid content
Free amino acids in potato tubers contribute to their nutritional value and processing quality. Exploring the natural variation in their accumulation...
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Stereoselective amino acid synthesis by photobiocatalytic oxidative coupling
Photobiocatalysis—where light is used to expand the reactivity of an enzyme—has recently emerged as a powerful strategy to develop chemistries that...
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Neopentyl glycol-based radiohalogen-labeled amino acid derivatives for cancer radiotheranostics
BackgroundL-type amino acid transporter 1 (LAT1) is overexpressed in various cancers; therefore, radiohalogen-labeled amino acid derivatives...
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Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19
Effective early-stage markers for predicting which patients are at risk of develo** SARS-CoV-2 infection have not been fully investigated. Here, we...
