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The Centrosome Cycle
Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and...
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Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction
Unlike normal cells, cancer cells frequently exhibit supernumerary centrosomes, leading to formation of multipolar spindles that can trigger cell...
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Unbiased Quantification of Golgi Scattering and Golgi–Centrosome Association
The vertebrate Golgi complex is a large dynamic organelle which undergoes morphological changes and fragmentation both as a part of normal...
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Regulation of exocytotic events by centrosome-analogous structures
Centrosomes, spindle pole bodies, and related structures, generally termed microtubule organising centres (MTOCs; Pickett-Heaps 1969), are best...
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The phosphorylation of PHF5A by TrkA-ERK1/2-ABL1 cascade regulates centrosome separation
During interphase, the newly duplicated pairs of centrosomes are held together by a centrosome linker, and the centrosome separation needs the...
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Nucleolin is required for multiple centrosome-associated functions in early vertebrate mitosis
Nucleolin is a multifunctional RNA-binding protein that resides predominantly not only in the nucleolus, but also in multiple other subcellular pools...
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Molecular landscape and functional characterization of centrosome amplification in ovarian cancer
High-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and extreme chromosome instability (CIN). Therapies targeting centrosome...
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Centrosome clustering control in osteoclasts through CCR5-mediated signaling
Osteoclasts uniquely resorb calcified bone matrices. To exert their function, mature osteoclasts maintain the cellular polarity and directional...
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Prolonged overexpression of PLK4 leads to formation of centriole rosette clusters that are connected via canonical centrosome linker proteins
Centrosome amplification is a hallmark of cancer and PLK4 is one of the responsible factors for cancer associated centrosome amplification. Increased...
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Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells
HIV-1 infection elevates the risk of develo** various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to...
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BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M
The activity of dynein is regulated by a number of adaptors that mediate its interaction with dynactin, effectively activating the motor complex...
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Centrosome Dysfunctions in Cancer
As major accomplishments and breakthroughs in centrosome research had been achieved by Theodor Boveri in reproductive cells with the invertebrate sea...
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SH2D4A promotes centrosome maturation to support spindle microtubule formation and mitotic progression
Mitotic progression requires the precise formation of spindle microtubules based on mature centrosomes. During the G2/M transition, centrosome...
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Laser ablation and fluid flows reveal the mechanism behind spindle and centrosome positioning
Few techniques are available for studying the nature of forces that drive subcellular dynamics. Here we develop two complementary ones. The first is...
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Epigenetic alterations impede epithelial-mesenchymal transition by modulating centrosome amplification and Myc/RAS axis in triple negative breast cancer cells
Alterations in centrosome proteins may result in centrosome abnormalities such as disorganized spindles and centrosome amplification, leading to...
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Centrosome amplification-related signature correlated with immune microenvironment and treatment response predicts prognosis and improves diagnosis of hepatocellular carcinoma by integrating machine learning and single-cell analyses
BackgroundCentrosome amplification is a well-recognized oncogenic driver of tumor initiation and progression across a variety of malignancies and has...
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The Centrosome and its Functions and Dysfunctions
The book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions...
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An updated view on the centrosome as a cell cycle regulator
The centrosome is a multifunctional organelle that is known primarily for its microtubule organising function. Centrosomal defects caused by changes...
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Cell and Molecular Biology of Centrosome Structure and Function
The centrosome field has seen enormous progress during the past few decades which spans the large areas of cell biology with new information on cell...
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The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle
The proper orientation of centrosome and spindle is essential for genome stability; however, the mechanism that governs these processes remains...
