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Membrane-bound chemoreception of bitter bile acids and peptides is mediated by the same subset of bitter taste receptors
The vertebrate sense of taste allows rapid assessment of the nutritional quality and potential presence of harmful substances prior to ingestion....
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Physiological activation of human and mouse bitter taste receptors by bile acids
Beside the oral cavity, bitter taste receptors are expressed in several non-gustatory tissues. Whether extra-oral bitter taste receptors function as...
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Bitter taste receptor activation by cholesterol and an intracellular tastant
Bitter taste sensing is mediated by type 2 taste receptors (TAS2Rs (also known as T2Rs)), which represent a distinct class of G-protein-coupled...
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Construction of a bioluminescence-based assay for bitter taste receptors (TAS2Rs)
In humans, a family of 25 bitter taste receptors (TAS2Rs) mediates bitter taste perception. A common approach to characterize bitter causative agents...
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BitterMatch: recommendation systems for matching molecules with bitter taste receptors
Bitterness is an aversive cue elicited by thousands of chemically diverse compounds. Bitter taste may prevent consumption of foods and jeopardize...
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Bitter taste TAS2R14 activation by intracellular tastants and cholesterol
Bitter taste receptors, particularly TAS2R14, play central roles in discerning a wide array of bitter substances, ranging from dietary components to...
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Morus alba L. Leaves (WML) Modulate Sweet (TAS1R) and Bitter (TAS2R) Taste in the Studies on Human Receptors – A New Perspective on the Utilization of White Mulberry Leaves in Food Production?
From the nutritional perspective, the main direction of the utilization of white mulberry ( Morus alba L.) parts so far has been to produce dietary...
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Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids
Extra-virgin olive oil (EVOO) is a critical component of the Mediterranean diet, which has been found beneficial to human health. Bitterness is often...
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Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis
The median eminence (ME) is a circumventricular organ at the base of the brain that controls body homeostasis. Tanycytes are its specialized glial...
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An update on extra-oral bitter taste receptors
Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family A G-protein coupled receptors (GPCRs), are of crucial...
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Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands
The human GPCR family comprises circa 800 members, activated by hundreds of thousands of compounds. Bitter taste receptors, TAS2Rs, constitute a...
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Functional molecular switches of mammalian G protein-coupled bitter-taste receptors
Bitter taste receptors (TAS2Rs) are a poorly understood subgroup of G protein-coupled receptors (GPCRs). The experimental structure of these...
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Reduction of bitter taste receptor gene family in folivorous colobine primates relative to omnivorous cercopithecine primates
Bitter taste perception is important in preventing animals from ingesting potentially toxic compounds. Whole-genome assembly (WGA) data have revealed...
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Mosquitoes do not Like Bitter
Chemical repellents play a crucial role in personal protection, serving as essential elements in reducing the transmission of vector-borne diseases....
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Neuroscience of taste: unlocking the human taste code
Since antiquity human taste has been divided into 4–5 taste qualities. We realized in the early 1970s that taste qualities vary between species and...
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The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review
Gastrointestinal nutrient sensing via taste receptors may contribute to weight loss, metabolic improvements, and a reduced preference for sweet and...
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3-oxo-C12:2-HSL, quorum sensing molecule from human intestinal microbiota, inhibits pro-inflammatory pathways in immune cells via bitter taste receptors
In the gut ecosystem, microorganisms regulate group behaviour and interplay with the host via a molecular system called quorum sensing (QS). The QS...
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Bitter Taste and Olfactory Receptors: Beyond Chemical Sensing in the Tongue and the Nose
AbstractThe Up-and-Coming-Scientist section of the current issue of the Journal of Membrane Biology features the invited essay by Dr. Mercedes...
