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rAAV-PHP.B escapes the mouse eye and causes lethality whereas rAAV9 can transduce aniridic corneal limbal stem cells without lethality
Recently safety concerns have been raised in connection with high doses of recombinant adeno-associated viruses (rAAV). Therefore, we undertook a...
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Gut barrier defects, intestinal immune hyperactivation and enhanced lipid catabolism drive lethality in NGLY1-deficient Drosophila
Intestinal barrier dysfunction leads to inflammation and associated metabolic changes. However, the relative impact of gut bacteria versus...
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Synthetic Lethality and Lung Cancer
Synthetic lethality happens between two genes that the mutation of either gene is feasible but the mutation of both concurrently leads to viability...
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Two mitochondrial DNA polymorphisms modulate cardiolipin binding and lead to synthetic lethality
Genetic screens have been used extensively to probe interactions between nuclear genes and their impact on phenotypes. Probing interactions between...
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Synthetic lethality in personalized cancer therapy
Genomic instability is one of the hallmarks of tumors that contributes to tumor heterogeneity and drug resistance. Genetically targeted cancer...
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Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore...
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Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting
A synthetic lethal relationship exists between disruption of polymerase theta (Polθ), and loss of either 53BP1 or homologous recombination (HR)...
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Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality
The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that...
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Exploring the DNA damage response pathway for synthetic lethality
Synthetic lethality (SL) describes a situation in which the occurrence of one genetic event maintains cell viability, whereas the co-occurrence of...
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Ghrelin prevents lethality in a rat endotoxemic model through central effects on the vagal pathway and adenosine A2B signaling
Accumulating evidence suggest that ghrelin plays a role as an antiseptic peptide. The present study aimed to clarify whether the brain may be...
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Deficiency of circadian clock gene Bmal1 exacerbates noncanonical inflammasome-mediated pyroptosis and lethality via Rev-erbα-C/EBPβ-SAA1 axis
Circadian arrhythmia has been linked to increased susceptibility to multiple inflammatory diseases, such as sepsis. However, it remains unclear how...
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Mitoribosomal synthetic lethality overcomes multidrug resistance in MYC-driven neuroblastoma
Mitochondria are central for cancer responses to therapy-induced stress signals. Refractory tumors often show attenuated sensitivity to apoptotic...
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Progress and promise of alternative animal and non-animal methods in biomedical research
Cell culture and invertebrate animal models reflect a significant evolution in scientific research by providing reliable evidence on the...
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Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities
Transcriptional co-regulators have been widely pursued as targets for disrupting oncogenic gene regulatory programs. However, many proteins in this...
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Animal Models of Infectious Diseases
Infectious diseases are of prime importance as they wreak havoc among humans since time immemorial. Even though we have found cures against several...
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Synthetic lethality between TP53 and ENDOD1
The atypical nuclease ENDOD1 functions with cGAS-STING in innate immunity. Here we identify a previously uncharacterized ENDOD1 function in DNA...
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Acute expression of human APOBEC3B in mice results in RNA editing and lethality
BackgroundRNA editing has been described as promoting genetic heterogeneity, leading to the development of multiple disorders, including cancer. The...
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Targeting DNA polymerase β elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia
Mismatch repair (MMR) deficiency has been linked to thiopurine resistance and hypermutation in relapsed acute lymphoblastic leukemia (ALL). However,...
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SARS-CoV-2 immunity in animal models
The COVID-19 pandemic, which was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to...
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Lethality risk markers by sex and age-group for COVID-19 in Mexico: a cross-sectional study based on machine learning approach
BackgroundMexico ranks fifth worldwide in the number of deaths due to COVID-19. Identifying risk markers through easily accessible clinical data...
