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Limiting systemic endocrine overtreatment in postmenopausal breast cancer patients with an ultralow classification of the 70-gene signature
PurposeGuidelines recommend endocrine treatment for estrogen receptor-positive (ER+) breast cancers for up to 10 years. Earlier data suggest that the...
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Nomogram prediction of the 70-gene signature (MammaPrint) binary and quartile categorized risk using medical history, imaging features and clinicopathological data among Chinese breast cancer patients
BackgroundThe 70-gene signature (70-GS, MammaPrint) test has been recommended by the main guidelines to evaluate prognosis and chemotherapy benefit...
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The 70-gene signature test as a prognostic and predictive biomarker in patients with invasive lobular breast cancer
PurposeGenomic expression assays provide prognostic information and guide adjuvant chemotherapy decisions for patients with estrogen receptor...
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Combining method of detection and 70-gene signature for enhanced prognostication of breast cancer
PurposeStudies have shown that screen detection by national screening programs is independently associated with better prognosis of breast cancer....
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Age-Independent Preoperative Chemosensitivity and 5-Year Outcome Determined by Combined 70- and 80-Gene Signature in a Prospective Trial in Early-Stage Breast Cancer
BackgroundThe Neoadjuvant Breast Symphony Trial (NBRST) demonstrated the 70-gene risk of distant recurrence signature, MammaPrint, and the 80-gene...
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Bioinformatics analysis of signature genes related to cell death in keratoconus
Keratoconus is corneal disease in which the progression of conical dilation of cornea leads to reduced visual acuity and even corneal perforation....
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The spike gene target failure (SGTF) genomic signature is highly accurate for the identification of Alpha and Omicron SARS-CoV-2 variants
The Alpha (B.1.1.7) and Omicron (B.1.1.529, BA.1, BA.4 and BA.5) variants of concern (VOC) share several mutations in their spike gene, including...
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A prognostic neural epigenetic signature in high-grade glioma
Neural–tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is limited. We present an epigenetically...
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Identification of a Notch transcriptomic signature for breast cancer
BackgroundDysregulated Notch signalling contributes to breast cancer development and progression, but validated tools to measure the level of Notch...
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Validation of a methylation-based signature for subventricular zone involvement in glioblastoma
PurposeGlioblastomas (GBM) with subventricular zone (SVZ) contact have previously been associated with a specific epigenetic fingerprint. We aim to...
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Combining a machine-learning derived 4-lncRNA signature with AFP and TNM stages in predicting early recurrence of hepatocellular carcinoma
BackgroundNear 70% of hepatocellular carcinoma (HCC) recurrence is early recurrence within 2-year post surgery. Long non-coding RNAs (lncRNAs) are...
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PTK2-associated gene signature could predict the prognosis of IPF
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with a poor prognosis. Current/available clinical prediction tools have...
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Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL
Recent genetic and molecular classification of DLBCL has advanced our knowledge of disease biology, yet were not designed to predict early events and...
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Identification of a cholesterol metabolism-related prognostic signature for multiple myeloma
Multiple myeloma (MM) is a prevalent hematological malignancy that poses significant challenges for treatment. Dysregulated cholesterol metabolism...
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Anoikis-related signature predicts prognosis and characterizes immune landscape of ovarian cancer
Ovarian cancer (OV) is the most lethal gynecological malignancy worldwide, with high recurrence rates. Anoikis, a newly-acknowledged form of...
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A novel pyroptosis-related gene signature exhibits distinct immune cells infiltration landscape in Wilms’ tumor
BackgroundWilms’ tumor (WT) is the most common renal tumor in childhood. Pyroptosis, a type of inflammation-characterized and immune-related...
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Featured lncRNA-based signature for discriminating prognosis and progression of hepatocellular carcinoma
Long non-coding RNAs (lncRNAs) have been implicated in carcinogenesis and progression of hepatocellular carcinoma (HCC). This study aimed to identify...
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Identification of an early survival prognostic gene signature for localized osteosarcoma patients
Osteosarcoma is the most prevalent bone tumor in pediatric patients. Neoadjuvant chemotherapy has improved osteosarcoma patient survival, however the...
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Improving arabic signature authentication with quantum inspired evolutionary feature selection
Offline signature verification (OSV) and identification systems have been used to identify individuals. It has become a significant task to validate...
