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Place des thérapeutiques moléculaires ciblées dans les carcinomes épidermoïdes des voies aérodigestives supérieures
The development of molecular targeted therapies in oncology is currently experiencing rapid growth, focusing primarily on two large categories of...
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Signalisation et développement tumoral
The development of head and neck squamous cell carcinoma (HNSCC) is a multi-stage and multicascade phenomenon. In the signaling cascade involved in...
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Stratégie de la prise en charge médicale dans les stades métastatiques
For a long time, advanced or metastatic renal carcinoma has presented a difficult therapeutic challenge in oncology practice. Only a few years ago,...
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CD95 et caspase-12 dans la réponse immunitaire
The death receptor CD95 belongs to the tumor necrosis factor (TNF) receptor super family. Lpr and Lpr cg mice and patients suffering from autoimmune...
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Les thérapies ciblées
En 2008, les progrès des connaissances en matière de carcinogenèse ont permis d’identifier des cibles moléculaires clés dans la genèse de nombreuses...
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Curcuma (partie I)
Since 2002, the Medline database referenced 900 published articles on turmeric. The most recent data has focused on its components, pharmacological...
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Quelles nouvelles à propos des antimétabolites en oncologie?
For oncologists and their patients, antimetabolites are cytotoxic agents that no longer hold any secrets. What cancer patient hasn’t received, or...
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Les alkylants
Alkylating agents belong to one of the oldest classes of anticancer drugs. Their therapeutic use dates back to the 1940’s with the drug...
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Pharmacologie des thérapeutiques ciblées
A better understanding of oncogenesis has allowed potential therapy targets to be identified in recent years. This has resulted in the development of...
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Citroflavonoïdes
Citrus bioflavonoids are polyphenols belonging to the flavonoid family of biological pigments. They are especially found in the peels of citrus...
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Les dérivés du platine
Platinum agents have been used for almost 30 years in the treatment of many types of cancers. Cisplatin, carboplatin and oxaliplatin are the main...
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Les poisons des topo-isomérases I
Topo-isomerase I is involved in resolving topological constraints in DNA. It transiently cleaves one of the two strands of DNA, passes the other...
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L’hespéridine, un antioxydant flavonoïde qui diminue le stress oxydatif et prévient les malformations fœtales au cours du diabète gestationnel expérimental
The aim of our experimentation is to evaluate a possible protective effect of hesperidine a citrus flavonoid on embryos antioxidant status in...
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Isolement du gallate de méthyle et évaluation de l’activité antibactérienne et antitumorale de quelques extraits deKlainedoxa gabonensis Pierre ex Engl.
Klainedoxa gabonensis Pierre ex Engl. est une plante couramment utilisée dans la médecine traditionnelle pour le traitement de nombreuses maladies,...
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Cancer avancé de la prostate et maladie osseuse métastatique
About 10,000 patients die of prostate cancer every year. Bone metastasis is found in 65 to 75% of advanced prostate cancer patients. This tumoral...
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Chimiothérapie des sarcomes des tissus mous métastatiques et localement avancés
Only two drugs, doxorubicin and ifosfamide, have demonstrated consistent response rates greater than 15% in phase-II trials with more than 30...