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Discovery of a novel lipid metabolism-related gene signature to predict outcomes and the tumor immune microenvironment in gastric cancer by integrated analysis of single-cell and bulk RNA sequencing
Gastric cancer (GC) is a pressing global clinical issue, with few treatment options and a poor prognosis. The onset and spread of stomach cancer are...
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The biological function of the N6-Methyladenosine reader YTHDC2 and its role in diseases
N6-methyladenosine (m6A) stands as the most prevalent modified form of RNA in eukaryotes, pivotal in various biological processes such as regulating...
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RNA Metabolism Governs Immune Function and Response
Inflammation is a complex process that protects our body from various insults such as infection, injury, and stress. Proper inflammation is...
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Contradictory roles of lipid metabolism in immune response within the tumor microenvironment
Complex interactions between the immune system and tumor cells exist throughout the initiation and development of cancer. Although the immune system...
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Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage
Once considered a waste product of anaerobic cellular metabolism, lactate has been identified as a critical regulator of tumorigenesis, maintenance,...
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A novel fatty acid metabolism-related signature identifies features of the tumor microenvironment and predicts clinical outcome in acute myeloid leukemia
BackgroundAcute myeloid leukemia (AML) is the most common malignancy of the hematological system, and there are currently a number of studies...
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FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-κB pathway
ObjectiveFucosyltransferases (FUTs) molecules have been identified to be involved in carcinogenesis of malignant tumors. Nevertheless, the biological...
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PGK1 : An Essential Player in Modulating Tumor Metabolism
Phosphoglycerate kinase 1 (PGK1) is the first enzyme in glycolysis to generate a molecule of ATP in the conversion of 1,3-bisphosphoglycerate...
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Amino acid metabolism in health and disease
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth,...
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Basic Insights into Tumor Microenvironment in Prostate Cancer
Prostate cancer, a prominent malignancy impacting men worldwide, is characterized by a dynamic and intricate interplay between cancer cells and their...
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Restricting tumor lactic acid metabolism using dichloroacetate improves T cell functions
BackgroundLactic acid produced by tumors has been shown to overcome immune surveillance, by suppressing the activation and function of T cells in the...
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Strategic disruption of cancer’s powerhouse: precise nanomedicine targeting of mitochondrial metabolism
Mitochondria occupy a central role in the biology of most eukaryotic cells, functioning as the hub of oxidative metabolism where sugars, fats, and...
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Expression of fibroblast activation protein in lung cancer and its correlation with tumor glucose metabolism and histopathology
PurposeTo explore the expression of fibroblast activation protein (FAP) in lung cancer (LC) and its correlation with tumor glucose metabolism and...
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Targeted inhibition of eIF5Ahpu suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer
Eukaryotic initiation factor 5A2 (eIF5A2) is overexpressed in many types of cancer, and spermidine-mediated eIF5A hypusination (eIF5A hpu ) appears to...
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NF2: An underestimated player in cancer metabolic reprogramming and tumor immunity
Neurofibromatosis type 2 ( NF2 ) is a tumor suppressor gene implicated in various tumors, including mesothelioma, schwannomas, and meningioma. As a...
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Intelligent nanovesicle for remodeling tumor microenvironment and circulating tumor chemoimmunotherapy amplification
Imperceptible examination and unideal treatment effect are still intractable difficulties for the clinical treatment of pancreatic ductal...
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Risk assessment model based on nucleotide metabolism-related genes highlights SLC27A2 as a potential therapeutic target in breast cancer
PurposeBreast cancer (BC) is the most prevalent malignant tumor worldwide among women, with the highest incidence rate. The mechanisms underlying...
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Role of lipid metabolism in hepatocellular carcinoma
Hepatocellular carcinoma (HCC), an aggressive malignancy with a dismal prognosis, poses a significant public health challenge. Recent research has...
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SLC38A5 promotes glutamine metabolism and inhibits cisplatin chemosensitivity in breast cancer
BackgroundSolute carrier family 38 member 5 (SLC38A5), as an amino acid transporter, play a vital role in cellular biological processes. In this...
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Identification of small molecule inhibitors against Lin28/let-7 to suppress tumor progression and its alleviation role in LIN28-dependent glucose metabolism
The reciprocal suppression of an RNA-binding protein LIN28 (human abnormal cell lineage 28) and miRNA Let-7 (Lethal 7) is considered to have a prime...
