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EMT-related protein expression in polyploid giant cancer cells and their daughter cells with different passages after triptolide treatment
Our previous work has demonstrated that paclitaxel can induce the formation of polyploid giant cancer cells (PGCCs) and inhibit tumor growth by...
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Editorial Expression of Concern: Triptolide inhibits angiogenesis in microvascular endothelial cells through regulation of miR-92a
An Editorial Expression of Concern to this paper has been published: https://doi.org/10.1007/s13105-021-00804-1
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Prodrug polymeric micelles integrating cancer-associated fibroblasts deactivation and synergistic chemotherapy for gastric cancer
BackgroundThe prognosis of patients with advanced gastric cancer (GC) remains unsatisfactory owing to distant metastasis and resistance to concurrent...
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Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer
PurposeCanonical Wnt/ β-catenin pathway is one mechanism being activated in platinum-resistant epithelial ovarian cancer (EOC). Detecting potential...
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Epigenetic effects of herbal medicine
Epigenetic memory is essential for life that governs the predefined functional features of cells. Recent evidence has indicated that the epigenetic...
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Therapeutic potential of natural products in inflammation: underlying molecular mechanisms, clinical outcomes, technological advances, and future perspectives
Chronic inflammation is a common underlying factor in many major diseases, including heart disease, diabetes, cancer, and autoimmune disorders, and...
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Advance on Chinese Medicine for Hypertensive Renal Damage: Focus on the Complex Molecular Mechanisms
Hypertensive renal damage (HRD) is a major cause of end-stage renal disease. Among the causes of end-stage renal disease, HRD accounts for nearly 34%...
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Redox-responsive self-assembly PEG nanoparticle enhanced triptolide for efficient antitumor treatment
Chemotherapy induces tumor cell death by directly damaging DNA or hindering cell mitosis. Some of the drawbacks of most chemotherapy are lack of...
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Triptolide prevents osteoarthritis via inhibiting hsa-miR-20b
Triptolide has been widely reported to exhibit potential therapeutic value in multiple inflammatory diseases, such as rheumatoid arthritis, systemic...
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Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023
BackgroundHerbal nanoparticles are made from natural herbs/medicinal plants, their extracts, or a combination with other nanoparticle carriers....
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Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes
ObjectiveTo determine the role of Tripterygium wilfordii multiglycoside (TGW) in the treatment of psoriatic dermatitis from a cellular immunological...
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Prediction of oral hepatotoxic dose of natural products derived from traditional Chinese medicines based on SVM classifier and PBPK modeling
The risk of drug-induced liver injury (DILI) poses a major challenge for development of natural products derived from traditional Chinese medicines...
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Triptolide inhibits Epstein-Barr nuclear antigen 1 expression by increasing sensitivity of mitochondria apoptosis of nasopharyngeal carcinoma cells
BackgroundEpstein-Barr virus (EBV) is widely found in nasopharyngeal carcinoma (NPC) tissue and associated with poor prognosis of patients. EBV...
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Author Correction: Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Promoter G-quadruplex folding precedes transcription and is controlled by chromatin
BackgroundFour-stranded G-quadruplexes (G4s) are DNA secondary structures in the human genome that are primarily found in active promoters associated...
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Peritoneal Implants and Drug Delivery
Peritoneal cavity owing to its physiological and anatomical features offers perfused capillaries to facilitate permeation for systemic delivery,...
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TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells
Cell division is the basis for the propagation of life and requires accurate duplication of all genetic information. DNA damage created during...
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A novel SPE-LC-MRM strategy for serum demethylzeylasteral quantitation developed with an 18O-labeled internal standard
Natural bioactive compounds (NBCs) are widely used in clinical treatment. For example, Tripterygium wilfordii Hook f. is commonly known in China as...
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Monomeric compounds from natural products for the treatment of pulmonary fibrosis: a review
Pulmonary fibrosis (PF) is the end stage of lung injury and chronic lung diseases that results in diminished lung function, respiratory failure, and...
