Search
Search Results
-
An α-chain modification rivals the effect of fetal hemoglobin in retarding the rate of sickle cell fiber formation
Adults with sickle cell disease bear a mutation in the β-globin gene, leading to the expression of sickle hemoglobin (HbS; α 2 β S 2 ). Adults also...
-
Automatic Sickle Cell Anaemia Detection Using Image Processing Technique
Sickle cell anaemia is a congenital red blood cell disorder which depicts an absence of sufficient red blood cells that are fit for transporting...
-
Contrast-enhanced CT evaluation of intra-abdominal vessels in sickle cell anemia
BackgroundSickle cell anemia (SCA) is a hereditary hematological disorder that affects millions of people worldwide. Abdominal crisis can result in...
-
Knowledge and awareness of sickle cell disease: a cross sectional study amongst unmarried adults in Nigeria’s capital city
Sickle cell disease is a genetic disorder characterised by the tendency of haemoglobin to polymerise and deform red blood cells to a sickle or...
-
Therapeutic perspective for children and young adults living with thalassemia and sickle cell disease
Hemoglobinopathies, including thalassemias and sickle cell disease, are the most common monogenic diseases worldwide, with estimated annual births of...
-
Evaluation of cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease using magnetic resonance imaging, echocardiography, and serum galectin-3
BackgroundMyocardial fibrosis has recently been proposed as one of the contributing factors to the diverse pathogenicity of cardiomyopathy in sickle...
-
Perceptions and preferences for genetic testing for sickle cell disease or trait: a qualitative study in Cameroon, Ghana and Tanzania
Sickle cell disease (SCD) is a single gene blood disorder characterised by frequent episodes of pain, chronic anaemic, acute chest syndrome, severe...
-
Comorbid ADHD and Pediatric Sickle Cell Disease: Prevalence and Risk Factors
Sickle cell disease (SCD) is a genetic blood condition that places youth at increased risk for deficits in complex attention suggestive of increased...
-
Bioethical Decision-Making About Somatic Cell Genome Editing: Sickle-Cell Disease as a Case Study
Somatic cell genome editing (SCGE) now allows exquisitely precise and targeted non-heritable changes to be made to human DNA. While SCGE has many...
-
Durable engraftment after pharmacological pre-transplant immune suppression followed by reduced-toxicity myeloablative haploidentical stem cell transplantation in highly HLA-immunized adults with sickle cell disease
Allogeneic stem cell transplantation (Allo-SCT) is the only rapidly available curative treatment modality in patients with severe sickle cell disease...
-
Sickle cell disease-related knowledge and perceptions of traditional healers in tribal communities in India: implications on sickle cell disease programme
Sickle cell disease (SCD) is a progressively debilitating genetic disease, and India is the second most affected nation in the prevalence of births...
-
Correlation of Pulmonary Arterial Hypertension with Laboratory Parameters in Sickle Cell Disease- A Retrospective Study
To study the prevalence of pulmonary arterial hypertension (PAH) in individuals with sickle cell disease (SCD) and its relationship with serological...
-
Rescue splenic artery embolization in an adult patient of sickle cell disease presented with acute splenic sequestration crisis
BackgroundSplenic sequestration crisis is a potentially fatal complication of sickle cell disease, mainly seen in young children. Only a few case...
-
Iron absorption in adults with sickle cell anemia: a stable-isotope approach
PurposeIron absorption in sickle cell anemia (SCA) remains unclear and studies in adults with SCA are scarce. The aim of this study was to evaluate...
-
-
Effect of Unmetabolized Folic Acid on Immunoinflammatory Markers in Sickle Cell Disease Patients Taking Folic Acid Supplementation
Folic acid (FA) supplementation in sickle cell disease (SCD) patients lead to accumulation of unmetabolized folic acid (UMFA) which might influence...
-
Enhancing diagnostic precision for acute chest syndrome in sickle cell disease: insights from dual-energy CT lung perfusion map**
PurposeAcute chest syndrome (ACS) is secondary to occlusion of the pulmonary vasculature and a potentially life-threatening complication of sickle...
-
An Examination of John Henryism in Adults Living with Sickle Cell Disease
BackgroundJohn Henryism (JH) is a behavioral predisposition for high-effort co** with adversity. JH has been associated with hypertension in Black...
-
Predictors of priapism incidence and recurrence in sickle cell disease patients
BackgroundSickle cell disease (SCD) is a prevalent genetic blood disorder with a high global incidence rate. Individuals with SCD experience lifelong...
-
Renal Doppler sonography as a non-invasive technique for early detection of reno-vascular changes in sickle cell disease in children
ObjectiveEarly identification of sickle renovascular changes via renal Doppler sonography among sickle cell disease patients to help in early...
