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How does age determine the development of human immune-mediated arthritis?
Does age substantially affect the emergence of human immune-mediated arthritis? Children do not usually develop immune-mediated articular...
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Pembrolizumab for the treatment of progressive multifocal leukoencephalopathy in China
The aim of this study is to analyze the clinical characteristics and outcomes of Chinese patients with progressive multifocal leukoencephalopathy...
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Immune cell dysregulation as a mediator of fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by dysregulation of the immune system and fibrosis in the skin and...
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Association of immune-related adverse events with COVID-19 pneumonia in lung cancer patients receiving immune checkpoint inhibitors: a cross-sectional study in China
BackgroundImmune checkpoint inhibitors (ICIs) are commonly used to treat lung cancer patients, but their use can lead to immune-related adverse...
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Dynamics of host immune responses and a potential function of Trem2hi interstitial macrophages in Pneumocystis pneumonia
BackgroundPneumocystis pneumonia (PCP) is a life-threatening opportunistic fungal infection with a high mortality rate in immunocompromised...
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Multifocal tuberculosis-associated immune reconstitution inflammatory syndrome – a case report of a complicated scenario
BackgroundTuberculosis (TB)-associated Immune reconstitution inflammatory syndrome (TB-IRIS) is an aberrant inflammatory response in TB patients with...
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Immunological Analysis of Cryptococcal Meningoencephalitis in a Murine Model
Cryptococcal meningoencephalitis (CM), caused by the fungal pathogen Cryptococcus neoformans species complex, can lead to high mortality or severe...
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Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data
BackgroundProgressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod.
Case presentation ...
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Pain-resolving immune mechanisms in neuropathic pain
Interactions between the immune and nervous systems are of central importance in neuropathic pain, a common and debilitating form of chronic pain...
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Update on Immune Checkpoint Inhibitor Enterocolitis
Purpose of ReviewImmune checkpoint inhibitor (ICI) therapy revolutionized the treatment of multiple solid and hematologic malignancies. Yet, with it...
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Made to order: emergency myelopoiesis and demand-adapted innate immune cell production
Definitive haematopoiesis is the process by which haematopoietic stem cells, located in the bone marrow, generate all haematopoietic cell lineages in...
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Cognitive impairments correlate with increased central nervous system immune activation after allogeneic haematopoietic stem cell transplantation
Murine studies indicate that, after allogeneic haematopoietic stem cell transplantation (aHSCT), donor-derived macrophages replace damaged microglia...
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Safety and efficacy of immune checkpoint inhibitors after allogeneic hematopoietic cell transplantation
The immune system plays a major role in preventing infections and cancers. Impairment in immunity may facilitate the development of neoplasia owing...
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Microorganisms in Pathogenesis and Management of Sjögren’s Syndrome
Sjögren’s syndrome (SS) is an autoimmune disease characterized by mononuclear cell infiltration of exocrine glands, leading to loss of function and...
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Complex Decisions in HIV-Related Cryptococcosis: Addressing Second Episodes of Cryptococcal Meningitis
Purpose of ReviewThis review highlights the difficulties in diagnosing and treating persons with a prior history of cryptococcal meningitis who...
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The Role of Interleukins in the Pathogenesis of Dermatological Immune-Mediated Diseases
Autoimmune inflammatory diseases are primarily characterized by deregulated expression of cytokines, which drive pathogenesis of these diseases. A...
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Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes
Sensing of cytosolic DNA of microbial or cellular/mitochondrial origin by cGAS initiates innate immune responses via the adaptor protein STING. It...
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The association between inflammatory markers in blood and cerebrospinal fluid: a systematic review and meta-analysis
BackgroundNeuroinflammatory processes have been hypothesized to play a role in the pathogenesis of psychiatric and neurological diseases. Studies on...
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Environmental Impact on Immune System
Environmental influences, either social or physical, can affect any aspect of human health, from disease onset (accumulating in their effects...