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The need to identify novel biomarkers for prediction of premature ovarian insufficiency (POI)
BackgroundPremature ovarian failure (POF)/premature ovarian insufficiency (POI) is characterized by disrupting ovarian function under 40 years old. A...
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Pathological mechanisms of neuroimmune response and multitarget disease-modifying therapies of mesenchymal stem cells in Parkinson’s disease
Parkinson's disease (PD) is a neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra (SN); the...
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Safety of Secukinumab from 1 Million Patient-Years of Exposure: Experience from Post-Marketing Setting and Clinical Trials
IntroductionSecukinumab is an anti-interleukin (IL)-17A monoclonal antibody indicated for multiple immunological disorders. Here, we aim to summarize...
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Mechanism of iron on the intestinal epithelium development in suckling piglets
This study aimed to investigate the mechanism of iron on intestinal epithelium development of suckling piglets. Compared with newborn piglets,...
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Correlation of angiogenic growth factors and inflammatory cytokines with the clinical phenotype of ocular tuberculosis
PurposeTo determine the correlation of angiogenic growth factors and inflammatory cytokines with the clinical phenotype of ocular tuberculosis (OTB).
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A comprehensive network map of IL-17A signaling pathway
Interleukin-17A (IL-17A) is one of the member of IL-17 family consisting of other five members (IL-17B to IL-17F). The Gamma delta (γδ) T cells and T...
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Identification of the characteristics of infiltrating immune cells in pulpitis and its potential molecular regulation mechanism by bioinformatics method
ObjectiveThe inflammation of dental pulp will also trigger an immune response. The purpose of this study is to demonstrate the immune cell’s function...
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Synbiotics in the Management of Breast Cancer
Breast cancer is more normal in females, and it is the second most common type of cancer globally and also responsible for the second cause of death...
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Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis causes cerebral dysfunction in the short...
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Inflammatory Mediators, Nociceptors, and Their Interactions in Pain
Inflammation produces pro-inflammatory mediators for the induction of pain. These mediators include inflammatory cytokines and chemokines, lipids,...
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How Has Molecular Biology Enhanced Our Undertaking of axSpA and Its Management
PurposeThis review aims at investigating pathophysiological mechanisms in spondyloarthritis (SpA). Analysis of genetic factors, immunological...
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Increasing Access to Effective Systemic Treatments in Patients with Moderate-to-Severe Psoriasis: Narrative Review
Psoriasis is a chronic, immune-mediated inflammatory disease with a worldwide prevalence ranging between 0.51 and 11.43%. It results in a large...
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Limonoids from the barks of Chukrasia tabularis and their anti-inflammatory activity
Two novel phragmalin type limonoids, Tabularisin Q ( 1 ) and Chuktabularin Y ( 18 ), together with 22 known limonoids have been separated from bark of Chuk...
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Exotic species in the Erbario Estense: new plants from the world to sixteenth-century Italy
AbstractRenaissance herbaria may provide precious information on exotic plants known or even introduced in Italy during the fifteenth and sixteenth...
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A comprehensive review on RNA interference-mediated targeting of interleukins and its potential therapeutic implications in colon cancer
Colon cancer is the world’s fourth leading cause of death. It is cancer of the latter part of the large intestine, i.e. the colon. Chronic...
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Discovery of natural dual inhibitors from ZINC database targeting thymic stromal lymphopoietin (TSLP) and interleukin-33 (IL-33) as potential anti-allergy agents
Allergic diseases, affecting millions worldwide, have shown a progressive increase in recent years. Existing anti-allergy drugs primarily target...
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Disease modification in inflammatory skin disorders: opportunities and challenges
Progress in understanding of the mechanisms underlying chronic inflammatory skin disorders, such as atopic dermatitis and psoriasis vulgaris, has led...
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Protective effect of Secukinumab on severe sepsis model rats by neutralizing IL-17A to inhibit IKBα/NFκB inflammatory signal pathway
Secukinumab is a specific neutralizing antibody for IL-17A. At present, numerous studies have confirmed the important role of IL-17A in sepsis, but...
