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Gene, Drug, and Tissue Engineering
This book combines discursive chapters that present the latest progress in molecular biology, drug discovery, organ-tissue engineering, and related...
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TRIM38 Induced in Respiratory Syncytial Virus-infected Cells Downregulates Type I Interferon Expression by Competing with TRIM25 to Bind RIG-I
Innate immune response is the first line of defense for the host against virus invasion. One important response is the synthesis and secretion of...
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Immune Gene Therapy of Cancer
Cancer is the second global cause of mortality. Conventional treatments, such as chemotherapy and radiotherapy, have not provided desirable...
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PCR-Based Assembly of Gene Sequences by Thermodynamically Balanced Inside-Out (TBIO) Gene Synthesis
The ability to enzymatically assemble DNA oligonucleotides into longer DNA duplexes in a process known as gene synthesis has wide-ranging...
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Metagenomic Gene Prediction Using Bidirectional LSTM
Genomics and microbial research have been revolutionized by the beginning of low-cost, high-throughput sequencing technologies. Which, in turn,...
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Recombinant Human Deoxyribonuclease I
Human deoxyribonuclease I (DNase I) is an endonuclease that catalyzes the hydrolysis of extracellular DNA and is just one of the numerous types of...
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Muscular Dystrophy: Mutations in the Dystrophin Gene
Muscular dystrophy (MD) is a heterogeneous group of genetic disorders characterized by progressive muscle degeneration and weakness, leading to...
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Regulatory Aspects of Gene Therapy and Cell Therapy Products A Global Perspective
This book discusses the different regulatory pathways for Advanced Therapy Medicinal Products implemented by national agencies in North and South...
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Insights into the mitochondrial cytochrome oxidase I (mt-COI) gene and wing morphometrics of Anopheles baimaii (Diptera: Culicidae) in malaria-endemic islands of Thailand
Anopheles baimaii (Diptera: Culicidae) significantly contributes to the transmission of parasites causing malaria in Southeast Asia and South Asia....
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The role of angiotensin I-converting enzyme gene polymorphism and global DNA methylation in the negative associations between urine di-(2-ethylhexyl) phthalate metabolites and serum adiponectin in a young Taiwanese population
BackgroundAdiponectin is a key protein produced in adipose tissue, with crucial involvement in multiple metabolic processes. Di-(2-ethylhexyl)...
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Gene Delivery to Chondrocytes
Delivering genes to chondrocytes offers new possibilities both clinically, for treating conditions that affect cartilage, and in the...
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Genetic Analysis by Targeted Misexpression and Gene Silencing
Analysis of gene function is crucial for understanding the mechanism of biological processes. Critical clues to gene functions in vivo can be...
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Recurrence-associated gene signature in patients with stage I non-small-cell lung cancer
Recurrent gene mutations and fusions in cancer patients are likely to be associated with cancer progression or recurrence by Vogelstein et al. ( Scienc...
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Biomanufacturing Aspects of Gene Therapy
The notion that genetic material could be transferred to a host patient for therapeutic benefit has been around for over half a century. However, it...
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Alginate in Gene and Vaccine Delivery
Gene and vaccine delivery offer promising technologies for the treatment of several diseases. However, they suffer from low transfection efficacy,...
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ERĪ± promotes transcription of tumor suppressor gene ApoA-I by establishing H3K27ac-enriched chromatin microenvironment in breast cancer cells
Apolipoprotein A-I (ApoA-I), the main protein component of high-density lipoprotein (HDL), plays a pivotal role in reverse cholesterol transport...
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Inferring a Gene Regulatory Network from Gene Expression Data. An Overview of Best Methods and a Reverse Engineering Approach
Gene Regulatory Networks (GRNs) are widely used to understand processes in cellular organisms. The spread of viruses and the development of new...
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Inferring Gene Regulatory Networks and Predicting the Effect of Gene Perturbations via IQCELL
IQCELL is a platform that infers Boolean gene regulatory networks from single-cell RNA sequencing data. Boolean networks can be simulated under...
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Association of baseline ROR1 and ROR2 gene expression with clinical outcomes in the I-SPY2 neoadjuvant breast cancer trial
PurposeROR1 and ROR2 are Type 1 tyrosine kinase-like orphan receptors for Wnt5a that are associated with breast cancer progression. Experimental...
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Multiobjective Rank Aggregation for Gene Prioritization
Rank aggregation involves consolidating multiple individual preference rankings of items to generate a consensus ranking. Typically framed as an...