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A recombinant virus-like particle vaccine against adenovirus-7 induces a potent humoral response
Adenoviruses (AdVs) cause infections in humans that range from mild to severe, and can cause outbreaks particularly in close contact settings....
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Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation
Airway inflammation and remodelling are important pathophysiologic features in asthma and other respiratory conditions. An intact epithelial cell...
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Safety and Immunogenicity of Homologous Recombinant Adenovirus Type 5-Vectored COVID-19 Vaccine Booster Dose in Healthy Adults Aged 18–60 Years: a Single-Center, Open-Label Trial
IntroductionThe waning antibody levels several months after prime vaccination and the persistent epidemics of severe acute respiratory syndrome...
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A potential bat adenovirus-based oncolytic virus targeting canine cancers
Although a canine adenovirus (CAdV)-based oncolytic virus (OV) candidate targeting canine tumors has been reported, its oncolytic effect could be...
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Viral Vector-Based Gene Therapy for Epilepsy: What Does the Future Hold?
In recent years, many pre-clinical studies have tested gene therapy approaches as possible treatments for epilepsy, following the idea that they may...
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Optimizing high-throughput viral vector characterization with density gradient equilibrium analytical ultracentrifugation
Viral vector-based gene therapies and vaccines require accurate characterization of capsid species. The current gold standard for assessing capsid...
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Interferon Alpha-Expressing Oncolytic Adenovirus for Treatment of Esophageal Adenocarcinoma
IntroductionEsophageal adenocarcinoma (EAC) has increased in incidence in Western countries, and its poor prognosis necessitates the development of...
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Quality Control for Adeno-Associated Viral Vector Production
Adeno-associated viral vectors (AAV) are frequently used by neuroscientists to deliver tools, such as biosensors and optogenetic and chemogenetic...
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In vivo and in vitro inhibition of SCLC by combining dual cancer-specific recombinant adenovirus with Etoposide
PurposeOncolytic virotherapy is emerging as an important modality in cancer treatment. In a previous study, we designed and constructed...
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Recombinant oncolytic adenovirus armed with CCL5, IL-12, and IFN-γ promotes CAR-T infiltration and proliferation in vivo to eradicate local and distal tumors
The efficacy of chimeric antigen receptor T (CAR-T) cells for solid tumors remains unsatisfactory due to the limited tumor infiltration and...
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A recombinant adenoviral vector with a specific tropism to CD4-positive cells: a new tool for HIV-1 inhibition
Gene therapy can be an option to overcome the side effects of chemotherapy and prevent the development of drug-resistant HIV viruses in HIV-infected...
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Modification of Adenovirus vaccine vector-induced immune responses by expression of a signalling molecule
Adenoviral vectors are being developed as vaccines against infectious agents and tumour-associated antigens, because of their ability to induce...
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Cerebral venous sinus thrombosis after adenovirus-vectored COVID-19 vaccination: review of the neurological-neuroradiological procedure
Cerebral venous and sinus thrombosis (CVST) after adenovirus-vectored COVID-19 ChAdOx1 nCov-19 (Oxford–AstraZeneca) and Ad26.COV2.S (Janssen/Johnson...
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Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration
The development of liver-based adeno-associated virus (AAV) gene therapies is facing concerns about limited efficiency and durability of transgene...
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Inactivated rabies-vectored SARS-CoV-2 vaccine provides long-term immune response unaffected by vector immunity
The objective of this study is to further analyze recombinant rabies virus-vectored SARS-CoV-2 vaccine, CORAVAX, as an effective COVID-19 vaccine...
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Adenovirus-mediated SIRT1 protects cochlear strial marginal cells in a D-gal-induced senescent model in vitro
BackgroundA primary obstacle in age-related hearing loss (ARHL) study is the lack of accelerated senescent models in vitro that explore the precise...
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A new insight into aggregation of oncolytic adenovirus Ad5-delta-24-RGD during CsCl gradient ultracentrifugation
Two-cycle cesium chloride (2 × CsCl) gradient ultracentrifugation is a conventional approach for purifying recombinant adenoviruses (rAds) for...
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A qPCR-Based Method for Quantification of Replication Competent Adenovirus (RCA) in Conditionally Replicating Oncolytic Adenoviruses
Production of conditionally replicating adenoviruses may unfortunately generate undesired replication-competent adenovirus (RCA) which raises safety...
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Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results
Checkpoint inhibitor (CPI) therapies provide limited benefit to patients with tumors of low immune reactivity. T cell-inducing vaccines hold promise...
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In vitro functional genetic modification of canine adenovirus type 2 genome by CRISPR/Cas9
Genetically modified oncolytic adenoviruses have been proposed as a vehicle for cancer therapy. However, several concerns, such as toxicity to normal...
