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In silico study to explore the mechanism of Toxoplasma-induced inflammation and target therapy based on sero and salivary Toxoplasma
We aimed to assess salivary and seroprevalence of Toxoplasma immunoglobulins in risky populations and evaluate drug docking targeting TgERP. A...
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The star target in SLE: IL-17
PurposeThe purpose of this review is to discuss the significance of IL-17 in SLE and the potential of IL-17-targeted therapy.
Background ...
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Narrative Review of the Emerging Therapeutic Role of Brodalumab in Difficult-to-Treat Psoriasis
Psoriatic involvement in areas of the body such as nails, palms and soles (palmoplantar), and scalp is associated with dramatically negative effects...
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A Practical Guide to the Management of Oral Candidiasis in Patients with Plaque Psoriasis Receiving Treatments That Target Interleukin-17
Plaque psoriasis is an immune-mediated inflammatory skin disease associated with the dysregulation of cytokines, especially those involved in the...
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Role of T Helper 17 in Cancer Pathology: A Double-Edge Sword
It has been revealed that patients suffering from chronic inflammatory disorders have a much higher risk of malignancy in the affected organs. CD4+ T...
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Obesity and Skin
Obesity is one of the major public health problems worldwide, which has been increasing with a rapid rate in past two decades. Objective way to...
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Inflammation and gut dysbiosis as drivers of CKD–MBD
Two decades ago, Kidney Disease: Improving Global Outcomes coined the term chronic kidney disease–mineral and bone disorder (CKD–MBD) to describe the...
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Bibliometric analysis on the structure and function of IL17
BackgroundInterleukin17 (IL17) is an important cytokine in host defense at mucosal surfaces and also mediates many autoimmune diseases, including...
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Pathophysiology of Generalized Pustular Psoriasis
Generalized pustular psoriasis (GPP) is a rare, severe form of pustular psoriasis characterized by widespread, recurrent episodes of neutrophil-rich...
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γδ T cells in oral diseases
Objectiveγδ T cells are a distinct subset of unconventional T cells, which link innate and adaptive immunity by secreting cytokines and interacting...
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Altered expression of NLRP3 inflammasome in pediatric patients with primary immune thrombocytopenia and its relation to disease activity
Immune thrombocytopenia (ITP) is an acquired autoimmune disease that is characterized by dysregulation of T cell-mediated autoimmunity. NLRP3...
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Circulating IL-17 reduces the risk of cisplatin-induced hearing loss in children: a bidirectional two-sample Mendelian randomization study
Studies have reported that cytokines and their related signaling pathways play a role in inner ear diseases. In clinical practice, approximately 50%...
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Molecular analyses of ADAMTS-1, -4, -5, and IL-17 a cytokine relationship in patients with ulcerative colitis
BackgroundUlcerative colitis (UC) is a chronic inflammatory bowel disease that develops due to the impaired immune response in genetically...
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Decoding the underlying mechanisms of Di-Tan-Decoction in treating intracerebral hemorrhage based on network pharmacology
BackgroundChinese medicine usually acts as "multi-ingredients, multi-targets and multi-pathways" on complex diseases, and these action modes reflect...
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Notch signaling regulates Th17 cells differentiation through PI3K/AKT/mTORC1 pathway and involves in the thyroid injury of autoimmune thyroiditis
PurposeAutoimmune Thyroiditis (AIT) is the most common thyroid disease; however, there were no measures to prevent the progression of the disease....
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IL-12 and IL-23 pathway inhibition in inflammatory bowel disease
Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of cytokines, have a key role in intestinal homeostasis and...
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Characterization of immunomodulatory factors and cells in bronchoalveolar lavage fluid for immune checkpoint inhibitor-related pneumonitis
As immune checkpoint inhibitors (ICIs) are widely used, a series of immune-related adverse events (irAEs) have been reported, including immune...
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Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance
Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and the immunosuppressive nature of the...
