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A Conjugation Vector Delivery System for Molecular Cloning into Cells of Bacteria of the Genus Bacillus
AbstractA delivery system for vectors for molecular cloning into bacterial cells of the genus Bacillus has been developed. A specific feature of the...
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Controlled Delivery of Plasmid DNA to Melanoma Tumors by Gene Electrotransfer
Gene electrotransfer (GET) is a reliable and effective physical method for in vivo delivery of plasmid DNA (pDNA). Several preclinical and clinical...
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Cell type-specific delivery by modular envelope design
The delivery of genetic cargo remains one of the largest obstacles to the successful translation of experimental therapies, in large part due to the...
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In vivo human T cell engineering with enveloped delivery vehicles
Viruses and virally derived particles have the intrinsic capacity to deliver molecules to cells, but the difficulty of readily altering cell-type...
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DNA-Based Hydrogel in Drug Delivery
DNA is perhaps the most important biopolymer that stores genetic information and is an integrated part of most living cells. Due to its high water...
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Drug Delivery Systems for Tendon and Ligament
Tendon and ligament injuries are the most difficult to heal musculoskeletal injuries, as they are bradytrophic tissues with poor vascularization,...
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Delivery of nucleic acids using nanomaterials
The increasing number of approved nucleic acid therapeutics demonstrates the potential for the prevention and treatment of a broad spectrum of...
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Effective delivery of anti-PD-L1 siRNA with human heavy chain ferritin (HFn) in acute myeloid leukemia cell lines
Because of the high biocompatibility, self-assembly capability, and CD71-mediated endocytosis, using human heavy chain ferritin (HFn) as a...
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Drug Delivery Systems and Cardiovascular Disease
Clinically, with the treatment of cardiovascular disease in addition to surgery and interventional therapy, drug therapy is also a common means. With...
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Focused ultrasound on the substantia nigra enables safe neurotensin-polyplex nanoparticle-mediated gene delivery to dopaminergic neurons intranasally and by blood circulation
Neurotensin-polyplex nanoparticles provide efficient gene transfection of nigral dopaminergic neurons when intracerebrally injected in preclinical...
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Formulation of Chitosan–Zein Nano-in-Microparticles for Oral DNA Delivery
Gene delivery via the oral route offers a promising strategy for improving DNA vaccination and gene-based therapy outcomes. The noninvasive nature of...
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E. Coli Nissle 1917 Based Carrier for DNA Delivery into Colorectal Carcinoma Cells
AbstractObjective: In recent years, bactofection—bacteria-mediated DNA transfer into mammalian cells is considered a promising approach to cancer...
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Biobased Nanomaterials in Drug Delivery
Biobased nanomaterials have emerged as a pivotal element in modern drug delivery, garnering substantial attention within scientific research. These...
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Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
Naturally generated lipid nanoparticles termed extracellular vesicles (EVs) hold significant promise as engineerable therapeutic delivery vehicles....
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Delivery technologies for women’s health applications
The treatment of women’s health-related conditions, including reproductive tract and pregnancy disorders, faces distinct challenges and...
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Design of double functionalized carbon nanotube for amphotericin B and genetic material delivery
In the present work, single wall carbon nanotubes (SWCNT) were successively functionalized with phospholipid DSPE-PEG carboxylic acid, and then, with...
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Novel Delivery Methods for CRISPR-Based Plant Genome Editing
Using modern genome editing tools, scientists are increasingly able to engineer animals and plants for better traits and improved downstream outcomes...
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Efficient and scalable gene delivery method with easily generated cationic carbon dots
Gene delivery is a complex process with several challenges when attempting to incorporate genetic material efficiently and safely into target cells....
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Pulmonary Delivery of Nucleic Acids
Pulmonary diseases affect millions of people worldwide and elicit symptoms that may evolve into severe conditions. Despite currently recommended...
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Biotin-modified Galactosylated Chitosan-gene Carrier in Hepatoma Cells Targeting Delivery
Our previous studies have successfully grafted biotin and galactose onto chitosan (CS) and synthesized biotin modified galactosylated chitosan...