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Impact of double-strand breaks induced by uv radiation on neuroinflammation and neurodegenerative disorders
Exposure to UV affects the development and growth of a wide range of organisms. Nowadays, researchers are focusing on the impact of UV radiation and...
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Characterizing the Repair of DNA Double-Strand Breaks: A Review of Surrogate Plasmid-Based Reporter Methods
DNA double-strand breaks (DSBs) are the most lethal genomic lesions that are induced endogenously during physiological reactions as well as by...
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BRD4 promotes resection and homology-directed repair of DNA double-strand breaks
Double-strand breaks (DSBs) are one of the most toxic forms of DNA damage and represent a major source of genomic instability. Members of the...
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Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells
BackgroundACTN4 is an actin-binding protein involved in many cellular processes, including cancer development. High ACTN4 expression is often...
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The meiotic topoisomerase VI B subunit (MTOPVIB) is essential for meiotic DNA double-strand break formation in barley (Hordeum vulgare L.)
Key messageIn barley ( Hordeum vulgare ), MTOPVIB is critical for meiotic DSB and accompanied SC and CO formation while dispensable for meiotic...
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Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity
BackgroundAnthracyclines including doxorubicin are essential components of many cancer chemotherapy regimens, but their cardiotoxicity severely...
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The BAP1 nuclear deubiquitinase is involved in the nonhomologous end-joining pathway of double-strand DNA repair through interaction with DNA-PK
BRCA1-associated protein 1 (BAP1) has emerged as a major tumor suppressor gene in diverse cancer types, notably in malignant pleural mesothelioma...
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Repair of DNA double-strand breaks in plant meiosis: role of eukaryotic RecA recombinases and their modulators
Homologous recombination during meiosis is crucial for the DNA double-strand breaks (DSBs) repair that promotes the balanced segregation of...
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Boric Acid Alters the Expression of DNA Double Break Repair Genes in MCF-7-Derived Breast Cancer Stem Cells
Breast cancer pathology ranks second in mortality among women worldwide due to the resistance of cancer stem cells in tumor tissue to radiotherapy...
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C-to-G editing generates double-strand breaks causing deletion, transversion and translocation
Base editors (BEs) introduce base substitutions without double-strand DNA cleavage. Besides precise substitutions, BEs generate low-frequency...
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A possible role for proinflammatory activation via cGAS-STING pathway in atherosclerosis induced by accumulation of DNA double-strand breaks
DNA damage contributes to atherosclerosis. However, causative links between DNA double-strand breaks (DSBs) and atherosclerosis have yet to be...
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A pair of primers facing at the double-strand break site enables to detect NHEJ-mediated indel mutations at a 1-bp resolution
The introduction of small insertion/deletion (indel) mutations in the coding region of genes by the site-specific nucleases such as Cas9 allows...
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Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells
BackgroundTriple-negative breast cancer (TNBC) is associated with aggressiveness and a poor prognosis. Besides surgery, radiotherapy serves as the...
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Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells
Increased frequency of DNA double strand breaks (DSBs) with aging suggests an age-associated decline in DSB repair efficiency, which is also...
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Tightly Focused Femtosecond Laser Radiation Induces DNA Double-Strand Breaks in Human Tumor Cells
We studied the formation of double-strand DNA breaks (DNA DSB) induced by femtosecond laser radiation in A549 human lung adenocarcinoma cells using...
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Analysis of DNA Double-Strand Break End Resection and Single-Strand Annealing in S. pombe
DNA double-strand break (DSB) end resection is an essential step for homologous recombination. It generates 3′ single-stranded DNA needed for the...
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ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
The maintenance of genomic stability requires the coordination of multiple cellular tasks upon the appearance of DNA lesions. RNA editing, the...
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Targeting double-strand break indel byproducts with secondary guide RNAs improves Cas9 HDR-mediated genome editing efficiencies
Programmable double-strand DNA breaks (DSBs) can be harnessed for precision genome editing through manipulation of the homology-directed repair (HDR)...
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BRCA1: a key player at multiple stages of homologous recombination in DNA double-strand break repair
As a key tumor suppressor in several cancers, BRCA1 is required for the maintenance of genomic stability. Extensive studies have revealed multiple...
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Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break
Genomic integrity is threatened by cytotoxic DNA double-strand breaks (DSBs), which must be resolved efficiently to prevent sequence loss,...
