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Fowl adenovirus serotype 4 enters leghorn male hepatocellular cells via the clathrin-mediated endocytosis pathway
Hepatitis-hydropericardium syndrome (HHS) induced by fowl adenovirus serotype-4 (FAdV-4) has caused large economic losses to the world poultry...
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Cardiac vein retroinjections provide an efficient approach for global left ventricular gene transfer with adenovirus and adeno-associated virus
Heart failure (HF) is a major burden worldwide, and new therapies are urgently needed. Gene therapy is a promising new approach to treat myocardial...
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The co-delivery of adenovirus-based immune checkpoint vaccine elicits a potent anti-tumor effect in renal carcinoma
Immune-based checkpoint therapy has made significant progress in cancer treatment, but its therapeutic effect is limited. A replication-defective...
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Recombinant fiber-1 protein of fowl adenovirus serotype 4 induces high levels of neutralizing antibodies in immunized chickens
Virulent fowl adenovirus serotype 4 (FAdV-4) causes hydropericardium syndrome (HPS) with high mortality in chickens, leading to significant economic...
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Spike-based adenovirus vectored COVID-19 vaccine does not aggravate heart damage after ischemic injury in mice
An unprecedented number of COVID-19 vaccination campaign are under way worldwide. The spike protein of SARS-CoV-2, which majorly binds to the host...
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Immunogenicity and clinical features relating to BNT162b2 messenger RNA COVID-19 vaccine, Ad26.COV2.S and ChAdOx1 adenoviral vector COVID-19 vaccines: a systematic review of non-interventional studies
BackgroundVaccination against Coronavirus disease 2019 (COVID-19) is an important means of controlling the pandemic, however they are expected to...
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Heterologous vaccination utilizing viral vector and protein platforms confers complete protection against SFTSV
Severe fever with thrombocytopenia syndrome virus was first discovered in 2009 as the causative agent of severe fever with thrombocytopenia syndrome....
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A Self-Biomineralized Novel Adenovirus Vectored COVID-19 Vaccine for Boosting Immunization of Mice
SARS-CoV-2 has caused more than 3.8 million deaths worldwide, and several types of COVID-19 vaccines are urgently approved for use, including...
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Improving the cytotoxic response of tumor-infiltrating lymphocytes towards advanced stage ovarian cancer with an oncolytic adenovirus expressing a human vIL-2 cytokine
While the presence of tumor-infiltrating lymphocytes (TILs) associates with improved survival prognosis in ovarian cancer (OvCa) patients, TIL...
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Hepatotoxicity in Adeno-Associated Viral Vector Gene Therapy
Purpose of ReviewRecombinant adeno-associated virus (rAAV) is the commonest viral vector used in gene therapies. With the increase in the number of...
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Viral Vector Upstream Processing and Clarification
The increasing number of gene therapy drugs entering the clinic targeting large population and/or large dosage diseases has forced gene therapy...
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Molecular characterization of a bovine adenovirus type 7 (Bovine Atadenovirus F) strain isolated from a systemically infected calf in Germany
Bovine adenovirus 7 (BAdV-7) is an unclassified member of the genus Atadenovirus with a worldwide distribution and has been reported to induce...
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Intrathecal Delivery of Viral Vector-Mediated Gene Therapy
Efforts to modify the genome to achieve a therapeutic goal though altering protein expression has therapy have witnessed significant advances in the...
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Viral Vector-Induced Ocular Hypertension in Mice
Viral transduction of the mouse trabecular meshwork using a variety of transgenes associated with glaucoma generates an inducible and reproducible...
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Aluminum particles generated during millisecond electric pulse application enhance adenovirus-mediated gene transfer in L929 cells
Gene electrotransfer is an attractive method of non-viral gene delivery. However, the mechanism of DNA penetration across the plasma membrane is...
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Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque
Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 has rapidly expanded into...
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Medicinal Plants Against Human Adenovirus Type 1 Infections: Ethnopharmacology, Chemistry, and Clinical and Preclinical Studies
Adenoviruses are double-stranded DNA viruses responsible for respiratory infections, eye infections, epidemic conjunctivitis, and gastroenteritis in...
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Characterization of a Species E Adenovirus Vector as a Zika virus vaccine
The development of a safe and efficacious Zika virus (ZIKV) vaccine remains a global health priority. In our previous work, we developed an...
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A recombinant virus-like particle vaccine against adenovirus-7 induces a potent humoral response
Adenoviruses (AdVs) cause infections in humans that range from mild to severe, and can cause outbreaks particularly in close contact settings....
