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Crystalline deposits in the cornea and various areas of the kidney as symptoms of an underlying monoclonal gammopathy: a case report
BackgroundPlasma cell dyscrasias (PCD) are characterized by an abnormal production of intact monoclonal immunoglobulins or parts such as heavy or...
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Update on kidney injury caused by multiple myeloma
Multiple myeloma (MM) is a form of clonal plasma cell malignancy that associates with clinical manifestations such as anemia, hypercalcemia, bone...
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Jan Gösta Waldenström and His World The Life and Work of a Giant in Science, Medicine and Humanity
Jan Waldenström (1906-1996) was the leading Swedish internist of the twentieth century. The first chapter of the book presents his remarkable family...
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Daratumumab with lenalidomide and dexamethasone in relapsed or refractory multiple myeloma patients – real world evidence analysis
We performed real world evidence (RWE) analysis of daratumumab, lenalidomide and dexamethasone (Dara-Rd) versus lenalidomide and dexamethasone (Rd)...
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Prognosis of young patients with monoclonal gammopathy of undetermined significance (MGUS)
Monoclonal gammopathy of undetermined significance (MGUS) is rare in young patients (age <40 years at diagnosis), with a prevalence of <0.3%,...
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POEMS syndrome with undetectable M-protein: a case report and literature review
BackgroundPolyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare plasma cell (PC) neoplasm with...
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Changing paradigms in diagnosis and treatment of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM)
Multiple myeloma (MM) is a highly heterogenous disease that exists along a continuous disease spectrum starting with premalignant conditions...
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Effectiveness of tixagevimab/cilgavimab in patients with hematological malignancies as a pre-exposure prophylaxis to prevent severe COVID-19: a Czech retrospective multicenter study
Despite lower virulence, the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019...
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Multiple myeloma, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment
Multiple myeloma (MM) is an incurable plasma cell malignancy, which is predominantly a disease of older adults (the median age at diagnosis is...
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Differences in genomic abnormalities among African individuals with monoclonal gammopathies using calculated ancestry
Multiple myeloma (MM) is two- to three-fold more common in African Americans (AAs) compared to European Americans (EAs). This striking disparity, one...
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Scleroderma Mimics
Scleroderma is named for the presence of its most characteristic quality, namely, skin sclerosis, in addition to symptoms that are commonly... -
Detection of MYD88 and CXCR4 mutations in cell-free DNA of patients with IgM monoclonal gammopathies
Liquid biopsyis being integrated into cancer diagnostics with profound therapeutic implications. However, its role in Waldenström’s Macroglobulinemia...
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Glomerulonephritis: immunopathogenesis and immunotherapy
‘Glomerulonephritis’ (GN) is a term used to describe a group of heterogeneous immune-mediated disorders characterized by inflammation of the...
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Paraproteins Associated with Malignancy
Monoclonal paraproteins and cryoglobulins with a monoclonal component are frequent in cancer patients. They may represent a poor prognostic index,... -
Coexistent transthyretin amyloid cardiomyopathy and monoclonal gammopathy: Diagnostic challenges and prognostic implications
Establishing an accurate diagnosis of amyloid subtype in patients with coexistent cardiac amyloidosis and monoclonal gammopathy is crucial due to...
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Giampaolo Merlini and the Pavia School
The great advances in the diagnosis and treatment of cardiac amyloidosis are the result of a collective effort inspired by the pioneering work of a... -
Systematic review and meta-analysis of the clinical features of MGRS
BackgroundIt is crucial to identify patients with monoclonal gammopathy of renal significance (MGRS) from those without MGRS but with monoclonal...
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Monoclonal Gammopathy of Undetermined Significance: Current Concepts and Future Prospects
Purpose of the ReviewMonoclonal gammopathy of undetermined significance (MGUS) is a highly prevalent precursor condition in the general population,...
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N-glycosylation of monoclonal light chains on routine MASS-FIX testing is a risk factor for MGUS progression
Our group previously demonstrated that M-protein light chain (LC) glycosylation can be detected on routine MASS-FIX testing. Glycosylation is...
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Crystalglobulin-associated nephropathy presenting as MGRS in a case of monoclonal B-cell lymphocytosis: a case report
BackgroundCrystalglobulin-associated nephropathy (CAN), a rare subtype of monoclonal gammopathy, usually associated with multiple myeloma and...