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Breast cancer patient-derived microtumors resemble tumor heterogeneity and enable protein-based stratification and functional validation of individualized drug treatment
Despite tremendous progress in deciphering breast cancer at the genomic level, the pronounced intra- and intertumoral heterogeneity remains a major...
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A real-world study and network pharmacology analysis of EGFR-TKIs combined with ZLJT to delay drug resistance in advanced lung adenocarcinoma
ObjectiveThis study aimed to explore the efficacy and safety of combining epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)...
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RETRACTED ARTICLE: Exosome-mediated lncRNA AFAP1-AS1 promotes trastuzumab resistance through binding with AUF1 and activating ERBB2 translation
BackgroundAlthough trastuzumab provides significant clinical benefit for HER2-positive breast cancers, responses are limited by the emergence of...
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Differential expression profiling of onco and tumor-suppressor genes from major-signaling pathways in Wilms’ tumor
PurposeWilms’ tumor is the most-frequent malignant-kidney tumor in children under 3–4 years of age and is caused by genetic alterations of oncogenes...
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YWHAH, a member of 14-3-3 family proteins, and PSME2, the proteasome activator subunit 2, are key host factors of Japanese encephalitis virus infection
BackgroundHost response to virus infection is key to the effective control and eventual elimination of viruses or infected cells; however, the...
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Trends in surface plasmon resonance biosensing: materials, methods, and machine learning
Surface plasmon resonance (SPR) proves to be one of the most effective methods of label-free detection and has been integral for the study of...
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Screening and identification of key biomarkers of depression using bioinformatics
We aimed to identify the molecular biomarkers of MDD disease progression to uncover potential mechanisms of major depressive disorder (MDD). In this...
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Overcoming Breast Cancer Resistance to Targeted, Chemo-, and Immuno Therapy: Mechanisms and Strategies to Overcome Resistance and Facilitate Drug Development
Breast cancer substantially impacts female mortality, and symptoms can differ among individuals. Hence, it is crucial to tailor treatment modalities...
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Insulin receptor alternative splicing in breast and prostate cancer
Cancer etiology represents an intricate, multifactorial orchestration where metabolically associated insulin-like growth factors (IGFs) and insulin...
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ERRα: unraveling its role as a key player in cell migration
Cell migration is essential throughout the life of multicellular organisms, and largely depends on the spatial and temporal regulation of...
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To be, or not to be: the dilemma of immunotherapy for non-small cell lung cancer harboring various driver mutations
IntroductionLung cancer is one of primary cancer type with high incidence and mortality, non-small cell lung cancer (NSCLC) is the most common type...
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Proteomics-based evaluation of the mechanism underlying vascular injury via DNA interstrand crosslinks, glutathione perturbation, mitogen-activated protein kinase, and Wnt and ErbB signaling pathways induced by crotonaldehyde
Crotonaldehyde (CRA)—one of the major environmental pollutants from tobacco smoke and industrial pollution—is associated with vascular injury (VI)....
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Quantitative systems pharmacology modeling of HER2-positive metastatic breast cancer for translational efficacy evaluation and combination assessment across therapeutic modalities
HER2-positive (HER2 + ) metastatic breast cancer (mBC) is highly aggressive and a major threat to human health. Despite the significant improvement in...
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Driver and targetable alterations in Chinese patients with small bowel carcinoma
PurposeSmall bowel carcinoma (SBA) is a rare gastrointestinal cancer with a poor prognosis. Recent genomic profiling studies revealed that the...
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Protein lipidation in health and disease: molecular basis, physiological function and pathological implication
Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal...
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Endogenous Mechanisms for Cardiomyocyte Regeneration
Cardiomyocyte proliferationCardiomyocyte proliferation is vital for development of the heartHeart. Mammalian cardiomyocytes (CMs) can vigorously...
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Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D
Recently accumulated evidence implicates a close association of vitamin D (VitD) insufficiency to the incidence and clinical manifestations of the...
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Detection of Cancer Biomarker by Advanced Biosensor
Early diagnosis and prompt therapy are critical for cancer treatment effectiveness. Advanced biosensorsBiosensors are emerging as inexpensive and...
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Inhibition of PFKFB3 in HER2-positive gastric cancer improves sensitivity to trastuzumab by inducing tumour vessel normalisation
BackgroundMultiple mechanisms have been proposed that lead to reduced effectiveness of trastuzumab in HER2-positive gastric cancer (GC), yet...
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Hyaluronan Metabolism and Tumor Progression
AbstractHereditary and somatic mutations initiating the origin of cancer cells are the key but not the only factor of tumor progression. Activation...
