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Drug Delivery Strategies in Alzheimer’s Disease
Over the past few decades, a concern over neurodegenerative disorders is growing proportionately with age, changing lifestyles, hereditary...
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Role of Inorganic Nanocomposite Materials in Drug Delivery Systems
Nanotechnology comprehends the study of various attributes of nanostructured materials at the molecular and sub-molecular levels. Nanoparticles (NPs)...
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Antibody–drug conjugate as targeted therapeutics against hepatocellular carcinoma: preclinical studies and clinical relevance
AbstractAn antibody–drug conjugate (ADC) is an advanced chemotherapeutic option with immense promises in treating many tumor. They are designed to...
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Drug-Induced Nephrotoxicity and Use of Biomarkers
Nephrotoxicity has been defined as renal injury that is caused due to direct or indirect exposure, mostly to drugs and other exogenous industrial or...
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Histopathology of Cutaneous Adverse Drug Reactions
Dermatopathology plays a key role in the assessment of drug-induced skin disease. Spongiotic and interface patterns are commonly encountered in...
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Diabetes and Cancer
Diabetes mellitus (DM) and cancers are leading causes of death worldwide. Recent evidence implies a significant association between DM (mainly type 2...
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Application of CRISPR–Cas Technology in Drug Development
The discovery of clustered regularly interspaced short palindromic repeat (CRISPR)-Cas technology has transformed the science of genome editing,...
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Drug resistance in ovarian cancer: from mechanism to clinical trial
Ovarian cancer is the leading cause of gynecological cancer-related death. Drug resistance is the bottleneck in ovarian cancer treatment. The...
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How gallic acid regulates molecular signaling: role in cancer drug resistance
Cancer is one of the deadliest and most heterogeneous diseases. Cancers often develop drug resistance, which can lead to treatment failure or...
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Strategies to Improve Drug Delivery Across the Blood–Brain Barrier for Glioblastoma
Purpose of ReviewGlioblastoma remains resistant to most conventional treatments. Despite scientific advances in the past three decades, there has...
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Cutaneous Adverse Drug Reactions
Unwanted drug reactions can be classified as type A and type B. Type A is pharmacologically determined, is based on the pharmaco-activity and...
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Alginate Based Hydrogel in Drug Delivery and Biomedical Applications
Alginates are polysaccharides resourced from natural sources such as brown algae and bacteria. Alginate is a natural, biodegradable, biocompatible...
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Drug-Induced/Iatrogenic Respiratory Disease: With Emphasis on Unusual, Rare, and Emergent Drug-Induced Reactions
Drugs have been known to cause adverse respiratory reactions since at least 1880, when Sir William Osler published an autopsy report of a fatal case...
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Nanovesicular-Mediated Intranasal Drug Therapy for Neurodegenerative Disease
Numerous neurodegenerative conditions, such as Alzheimer’s, Huntington’s, Parkinson’s, amyotrophic lateral sclerosis, and glioblastoma multiform are...
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Chemoresistance Mechanisms in Non-Small Cell Lung Cancer—Opportunities for Drug Repurposing
Globally, lung cancer contributes significantly to the public health burden–associated mortality. As this form of cancer is insidious in nature,...
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lncRNA-microRNA axis in cancer drug resistance: particular focus on signaling pathways
Cancer drug resistance remains a formidable challenge in modern oncology, necessitating innovative therapeutic strategies. The convergence of...
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The Hallmarks of Liver Fluke Related Cholangiocarcinoma: Insight into Drug Target Possibility
Cholangiocarcinoma (CCA) is a malignant tumor of the biliary tree that is classified into three groups based on its anatomic location: intrahepatic...
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Anti-cancer drug-mediated increase in mitochondrial mass limits the application of metabolic viability-based MTT assay in cytotoxicity screening
The high-throughput metabolic viability-based colorimetric MTT test is commonly employed to screen the cytotoxicity of different chemotherapeutic...
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The anti-neoplastic effect of doxycycline in osteosarcoma as a metalloproteinase (MMP) inhibitor: a systematic review
BackgroundOsteosarcoma is a very aggressive primary bone tumour, affecting mainly young populations. Most cases diagnosed have distant macro- and...
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The Temozolomide–Doxorubicin paradox in Glioblastoma in vitro–in silico preclinical drug-screening
Adjuvant Temozolomide is considered the front-line Glioblastoma chemotherapeutic treatment; yet not all patients respond. Latest trends in clinical...
